High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia

Abstract High-frequency peripheral nerve stimulation has emerged as a noninvasive alternative to thalamic deep brain stimulation for some patients with essential tremor. It is not known whether such techniques might be effective for movement disorders in children, nor is the mechanism and transmissi...

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Autores principales:	Estefanía Hernandez-Martin, Enrique Arguelles, Yifei Zheng, Ruta Deshpande, Terence D. Sanger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b09bd81b4c94850bd5e92da1715014a
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spelling	oai:doaj.org-article:3b09bd81b4c94850bd5e92da1715014a2021-12-02T16:45:10ZHigh-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia10.1038/s41598-021-88114-w2045-2322https://doaj.org/article/3b09bd81b4c94850bd5e92da1715014a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88114-whttps://doaj.org/toc/2045-2322Abstract High-frequency peripheral nerve stimulation has emerged as a noninvasive alternative to thalamic deep brain stimulation for some patients with essential tremor. It is not known whether such techniques might be effective for movement disorders in children, nor is the mechanism and transmission of the peripheral stimuli to central brain structures understood. This study was designed to investigate the fidelity of transmission from peripheral nerves to thalamic nuclei in children with dystonia undergoing deep brain stimulation surgery. The ventralis intermediate (VIM) thalamus nuclei showed a robust evoked response to peripheral high-frequency burst stimulation, with a greatest response magnitude to intra-burst frequencies between 50 and 100 Hz, and reliable but smaller responses up to 170 Hz. The earliest response occurred at 12–15 ms following stimulation onset, suggesting rapid high-fidelity transmission between peripheral nerve and thalamic nuclei. A high-bandwidth, low-latency transmission path from peripheral nerve to VIM thalamus is consistent with the importance of rapid and accurate sensory information for the control of coordination and movement via the cerebello-thalamo-cortical pathway. Our results suggest the possibility of non-invasive modulation of thalamic activity in children with dystonia, and therefore the possibility that a subset of children could have beneficial clinical response without the need for invasive deep brain stimulation.Estefanía Hernandez-MartinEnrique ArguellesYifei ZhengRuta DeshpandeTerence D. SangerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Estefanía Hernandez-Martin Enrique Arguelles Yifei Zheng Ruta Deshpande Terence D. Sanger High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
description	Abstract High-frequency peripheral nerve stimulation has emerged as a noninvasive alternative to thalamic deep brain stimulation for some patients with essential tremor. It is not known whether such techniques might be effective for movement disorders in children, nor is the mechanism and transmission of the peripheral stimuli to central brain structures understood. This study was designed to investigate the fidelity of transmission from peripheral nerves to thalamic nuclei in children with dystonia undergoing deep brain stimulation surgery. The ventralis intermediate (VIM) thalamus nuclei showed a robust evoked response to peripheral high-frequency burst stimulation, with a greatest response magnitude to intra-burst frequencies between 50 and 100 Hz, and reliable but smaller responses up to 170 Hz. The earliest response occurred at 12–15 ms following stimulation onset, suggesting rapid high-fidelity transmission between peripheral nerve and thalamic nuclei. A high-bandwidth, low-latency transmission path from peripheral nerve to VIM thalamus is consistent with the importance of rapid and accurate sensory information for the control of coordination and movement via the cerebello-thalamo-cortical pathway. Our results suggest the possibility of non-invasive modulation of thalamic activity in children with dystonia, and therefore the possibility that a subset of children could have beneficial clinical response without the need for invasive deep brain stimulation.
format	article
author	Estefanía Hernandez-Martin Enrique Arguelles Yifei Zheng Ruta Deshpande Terence D. Sanger
author_facet	Estefanía Hernandez-Martin Enrique Arguelles Yifei Zheng Ruta Deshpande Terence D. Sanger
author_sort	Estefanía Hernandez-Martin
title	High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
title_short	High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
title_full	High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
title_fullStr	High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
title_full_unstemmed	High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
title_sort	high-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b09bd81b4c94850bd5e92da1715014a
work_keys_str_mv	AT estefaniahernandezmartin highfidelitytransmissionofhighfrequencyburststimulifromperipheralnervetothalamicnucleiinchildrenwithdystonia AT enriquearguelles highfidelitytransmissionofhighfrequencyburststimulifromperipheralnervetothalamicnucleiinchildrenwithdystonia AT yifeizheng highfidelitytransmissionofhighfrequencyburststimulifromperipheralnervetothalamicnucleiinchildrenwithdystonia AT rutadeshpande highfidelitytransmissionofhighfrequencyburststimulifromperipheralnervetothalamicnucleiinchildrenwithdystonia AT terencedsanger highfidelitytransmissionofhighfrequencyburststimulifromperipheralnervetothalamicnucleiinchildrenwithdystonia
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High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia

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