Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis

Abstract Aeromonas sobria is opportunistic pathogen frequently found in environment and food. Interfering with its quorum sensing (QS) system could be a promising way to alleviate its virulence. In this study, curcumin liposomes were prepared and their characteristics like particle size, zeta potent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ting Ding, Tingting Li, Zhi Wang, Jianrong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b09d2a95873452cb92179b5d9b0eafc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b09d2a95873452cb92179b5d9b0eafc
record_format	dspace
spelling	oai:doaj.org-article:3b09d2a95873452cb92179b5d9b0eafc2021-12-02T12:31:47ZCurcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis10.1038/s41598-017-08986-92045-2322https://doaj.org/article/3b09d2a95873452cb92179b5d9b0eafc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08986-9https://doaj.org/toc/2045-2322Abstract Aeromonas sobria is opportunistic pathogen frequently found in environment and food. Interfering with its quorum sensing (QS) system could be a promising way to alleviate its virulence. In this study, curcumin liposomes were prepared and their characteristics like particle size, zeta potential, PDI (Polymey Disperse Index), encapsulation efficiency and loading capacity were measured. The quorum sensing inhibitory effect of curcumin liposomes under sub-MIC (Minimum Inhibitory Concentration) on siderophore production, swimming and swarming motility, extracellular proteases, biofilm formation and AHLs (N-acylhomoserine lactones) production of A. sobria were also determined. The results showed that, the curcumin liposomes with high encapsulation capacity (84.51 ± 0.58%) were stable and homogeneous. QS-regulated phenotypes of the pathogen were significantly inhibited by curcumin liposomes. The in silico analysis revealed that the QS system of A. sobria may be inhibited by released curcumin from curcumin liposomes through interacting with the built LuxI type protein and blocking the production of AHLs.Ting DingTingting LiZhi WangJianrong LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ting Ding Tingting Li Zhi Wang Jianrong Li Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis
description	Abstract Aeromonas sobria is opportunistic pathogen frequently found in environment and food. Interfering with its quorum sensing (QS) system could be a promising way to alleviate its virulence. In this study, curcumin liposomes were prepared and their characteristics like particle size, zeta potential, PDI (Polymey Disperse Index), encapsulation efficiency and loading capacity were measured. The quorum sensing inhibitory effect of curcumin liposomes under sub-MIC (Minimum Inhibitory Concentration) on siderophore production, swimming and swarming motility, extracellular proteases, biofilm formation and AHLs (N-acylhomoserine lactones) production of A. sobria were also determined. The results showed that, the curcumin liposomes with high encapsulation capacity (84.51 ± 0.58%) were stable and homogeneous. QS-regulated phenotypes of the pathogen were significantly inhibited by curcumin liposomes. The in silico analysis revealed that the QS system of A. sobria may be inhibited by released curcumin from curcumin liposomes through interacting with the built LuxI type protein and blocking the production of AHLs.
format	article
author	Ting Ding Tingting Li Zhi Wang Jianrong Li
author_facet	Ting Ding Tingting Li Zhi Wang Jianrong Li
author_sort	Ting Ding
title	Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis
title_short	Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis
title_full	Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis
title_fullStr	Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis
title_full_unstemmed	Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis
title_sort	curcumin liposomes interfere with quorum sensing system of aeromonas sobria and in silico analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b09d2a95873452cb92179b5d9b0eafc
work_keys_str_mv	AT tingding curcuminliposomesinterferewithquorumsensingsystemofaeromonassobriaandinsilicoanalysis AT tingtingli curcuminliposomesinterferewithquorumsensingsystemofaeromonassobriaandinsilicoanalysis AT zhiwang curcuminliposomesinterferewithquorumsensingsystemofaeromonassobriaandinsilicoanalysis AT jianrongli curcuminliposomesinterferewithquorumsensingsystemofaeromonassobriaandinsilicoanalysis
_version_	1718394271071993856

Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis

Ejemplares similares