Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8

During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of...

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Autores principales:	Biljana Božić, Vladimir Polaček, Ivana Vučićević, Dejan Vidanović, Nikola Vasković, Jasna Prodanov-Radulović, Sanja Aleksić-Kovačević
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	avian influenza hens h5n8 mute swans pancreatic lesions Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/3b0b776061a84798a8e0a358e7f7c911
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spelling	oai:doaj.org-article:3b0b776061a84798a8e0a358e7f7c9112021-11-17T21:27:52ZMorphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N81820-744810.2478/acve-2018-0018https://doaj.org/article/3b0b776061a84798a8e0a358e7f7c9112018-06-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0018https://doaj.org/toc/1820-7448During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of hens in rural households. Pancreatic tissues from avian influenza H5N8 positive mute swans and hens that died during this outbreak were collected to determine the character of morphological lesions and the distribution of the viral antigen in this organ. Macroscopic examination of the pancreas of mute swans revealed hemorrhages as well as necrosis, while there were no macroscopic visible lesions in the pancreas of infected hens. Despite the different macroscopic finding, microscopic examination of the pancreas of both infected bird species revealed lesions in the form of acute pancreatitis and multifocal acinar necrosis. The viral antigen was abundantly expressed in the cytoplasm and nucleus of necrotic cells, as well as in macrophages in both examined bird species. Immunohistochemical expression of the viral antigen in the pancreas was strongly consistent with histological lesions. According to the above described findings, it could be concluded that highly pathogenic avian influenza virus H5N8 has a high affinity to pancreatic tissue in both mute swans and hens and the distribution and the character of the lesions in the pancreas are similar in both bird species.Biljana BožićVladimir PolačekIvana VučićevićDejan VidanovićNikola VaskovićJasna Prodanov-RadulovićSanja Aleksić-KovačevićSciendoarticleavian influenzahensh5n8mute swanspancreatic lesionsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 2, Pp 217-223 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	avian influenza hens h5n8 mute swans pancreatic lesions Veterinary medicine SF600-1100
spellingShingle	avian influenza hens h5n8 mute swans pancreatic lesions Veterinary medicine SF600-1100 Biljana Božić Vladimir Polaček Ivana Vučićević Dejan Vidanović Nikola Vasković Jasna Prodanov-Radulović Sanja Aleksić-Kovačević Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8
description	During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of hens in rural households. Pancreatic tissues from avian influenza H5N8 positive mute swans and hens that died during this outbreak were collected to determine the character of morphological lesions and the distribution of the viral antigen in this organ. Macroscopic examination of the pancreas of mute swans revealed hemorrhages as well as necrosis, while there were no macroscopic visible lesions in the pancreas of infected hens. Despite the different macroscopic finding, microscopic examination of the pancreas of both infected bird species revealed lesions in the form of acute pancreatitis and multifocal acinar necrosis. The viral antigen was abundantly expressed in the cytoplasm and nucleus of necrotic cells, as well as in macrophages in both examined bird species. Immunohistochemical expression of the viral antigen in the pancreas was strongly consistent with histological lesions. According to the above described findings, it could be concluded that highly pathogenic avian influenza virus H5N8 has a high affinity to pancreatic tissue in both mute swans and hens and the distribution and the character of the lesions in the pancreas are similar in both bird species.
format	article
author	Biljana Božić Vladimir Polaček Ivana Vučićević Dejan Vidanović Nikola Vasković Jasna Prodanov-Radulović Sanja Aleksić-Kovačević
author_facet	Biljana Božić Vladimir Polaček Ivana Vučićević Dejan Vidanović Nikola Vasković Jasna Prodanov-Radulović Sanja Aleksić-Kovačević
author_sort	Biljana Božić
title	Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8
title_short	Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8
title_full	Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8
title_fullStr	Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8
title_full_unstemmed	Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8
title_sort	morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/3b0b776061a84798a8e0a358e7f7c911
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Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8

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