Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors

Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors

Primary effusion lymphoma (PEL) has a very poor prognosis. Here, the authors perform H3K27ac HiChIP in PEL cells and generate the PEL enhancer connectome, linking enhancers and promoters in PEL, as well as super-enhancers to dependency factors.

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Auteurs principaux: Chong Wang, Luyao Zhang, Liangru Ke, Weiyue Ding, Sizun Jiang, Difei Li, Yohei Narita, Isabella Hou, Jun Liang, Shijun Li, Haipeng Xiao, Eva Gottwein, Kenneth M. Kaye, Mingxiang Teng, Bo Zhao
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/3b0cb7b6da294c72b4d1187e13551c79
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spelling oai:doaj.org-article:3b0cb7b6da294c72b4d1187e13551c792021-12-02T14:16:32ZPrimary effusion lymphoma enhancer connectome links super-enhancers to dependency factors10.1038/s41467-020-20136-w2041-1723https://doaj.org/article/3b0cb7b6da294c72b4d1187e13551c792020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20136-whttps://doaj.org/toc/2041-1723Primary effusion lymphoma (PEL) has a very poor prognosis. Here, the authors perform H3K27ac HiChIP in PEL cells and generate the PEL enhancer connectome, linking enhancers and promoters in PEL, as well as super-enhancers to dependency factors.Chong WangLuyao ZhangLiangru KeWeiyue DingSizun JiangDifei LiYohei NaritaIsabella HouJun LiangShijun LiHaipeng XiaoEva GottweinKenneth M. KayeMingxiang TengBo ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chong Wang
Luyao Zhang
Liangru Ke
Weiyue Ding
Sizun Jiang
Difei Li
Yohei Narita
Isabella Hou
Jun Liang
Shijun Li
Haipeng Xiao
Eva Gottwein
Kenneth M. Kaye
Mingxiang Teng
Bo Zhao
Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
description Primary effusion lymphoma (PEL) has a very poor prognosis. Here, the authors perform H3K27ac HiChIP in PEL cells and generate the PEL enhancer connectome, linking enhancers and promoters in PEL, as well as super-enhancers to dependency factors.
format article
author Chong Wang
Luyao Zhang
Liangru Ke
Weiyue Ding
Sizun Jiang
Difei Li
Yohei Narita
Isabella Hou
Jun Liang
Shijun Li
Haipeng Xiao
Eva Gottwein
Kenneth M. Kaye
Mingxiang Teng
Bo Zhao
author_facet Chong Wang
Luyao Zhang
Liangru Ke
Weiyue Ding
Sizun Jiang
Difei Li
Yohei Narita
Isabella Hou
Jun Liang
Shijun Li
Haipeng Xiao
Eva Gottwein
Kenneth M. Kaye
Mingxiang Teng
Bo Zhao
author_sort Chong Wang
title Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
title_short Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
title_full Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
title_fullStr Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
title_full_unstemmed Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
title_sort primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3b0cb7b6da294c72b4d1187e13551c79
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