Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight

Abstract Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome d...

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Autores principales:	Jennifer L. LaBarre, Muraly Puttabyatappa, Peter X. K. Song, Jaclyn M. Goodrich, Ling Zhou, Thekkelnaycke M. Rajendiran, Tanu Soni, Steven E. Domino, Marjorie C. Treadwell, Dana C. Dolinoy, Vasantha Padmanabhan, Charles F. Burant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b0d83d84e314f489cd93629715c9c1b
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spelling	oai:doaj.org-article:3b0d83d84e314f489cd93629715c9c1b2021-12-02T19:02:37ZMaternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight10.1038/s41598-020-71081-z2045-2322https://doaj.org/article/3b0d83d84e314f489cd93629715c9c1b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-71081-zhttps://doaj.org/toc/2045-2322Abstract Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome during pregnancy and identified lipids associated with Fenton BW z-score and the umbilical cord blood (CB) lipidome. Lipidomics was performed on first trimester maternal plasma (M1), delivery maternal plasma (M3), and CB plasma in 106 mother-infant dyads. Shifts in the maternal and CB lipidome were consistent with the selective transport of long-chain polyunsaturated fatty acids (PUFA) as well as lysophosphatidylcholine (LysoPC) and lysophosphatidylethanolamine (LysoPE) species into CB. Partial correlation networks demonstrated fluctuations in correlations between lipid groups at M1, M3, and CB, signifying differences in lipid metabolism. Using linear models, LysoPC and LysoPE groups in CB were positively associated with BW. M1 PUFA containing triglycerides (TG) and phospholipids were correlated with CB LysoPC and LysoPE species and total CB polyunsaturated TGs. These results indicate that early gestational maternal lipid levels influence the CB lipidome and its relationship with BW, suggesting an opportunity to modulate maternal diet and improve long-term offspring cardiometabolic health.Jennifer L. LaBarreMuraly PuttabyatappaPeter X. K. SongJaclyn M. GoodrichLing ZhouThekkelnaycke M. RajendiranTanu SoniSteven E. DominoMarjorie C. TreadwellDana C. DolinoyVasantha PadmanabhanCharles F. BurantNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer L. LaBarre Muraly Puttabyatappa Peter X. K. Song Jaclyn M. Goodrich Ling Zhou Thekkelnaycke M. Rajendiran Tanu Soni Steven E. Domino Marjorie C. Treadwell Dana C. Dolinoy Vasantha Padmanabhan Charles F. Burant Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
description	Abstract Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome during pregnancy and identified lipids associated with Fenton BW z-score and the umbilical cord blood (CB) lipidome. Lipidomics was performed on first trimester maternal plasma (M1), delivery maternal plasma (M3), and CB plasma in 106 mother-infant dyads. Shifts in the maternal and CB lipidome were consistent with the selective transport of long-chain polyunsaturated fatty acids (PUFA) as well as lysophosphatidylcholine (LysoPC) and lysophosphatidylethanolamine (LysoPE) species into CB. Partial correlation networks demonstrated fluctuations in correlations between lipid groups at M1, M3, and CB, signifying differences in lipid metabolism. Using linear models, LysoPC and LysoPE groups in CB were positively associated with BW. M1 PUFA containing triglycerides (TG) and phospholipids were correlated with CB LysoPC and LysoPE species and total CB polyunsaturated TGs. These results indicate that early gestational maternal lipid levels influence the CB lipidome and its relationship with BW, suggesting an opportunity to modulate maternal diet and improve long-term offspring cardiometabolic health.
format	article
author	Jennifer L. LaBarre Muraly Puttabyatappa Peter X. K. Song Jaclyn M. Goodrich Ling Zhou Thekkelnaycke M. Rajendiran Tanu Soni Steven E. Domino Marjorie C. Treadwell Dana C. Dolinoy Vasantha Padmanabhan Charles F. Burant
author_facet	Jennifer L. LaBarre Muraly Puttabyatappa Peter X. K. Song Jaclyn M. Goodrich Ling Zhou Thekkelnaycke M. Rajendiran Tanu Soni Steven E. Domino Marjorie C. Treadwell Dana C. Dolinoy Vasantha Padmanabhan Charles F. Burant
author_sort	Jennifer L. LaBarre
title	Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
title_short	Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
title_full	Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
title_fullStr	Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
title_full_unstemmed	Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
title_sort	maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3b0d83d84e314f489cd93629715c9c1b
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Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight

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