Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease
Osamu Kano1,2, Ken Ikeda2, Tetsuhito Kiyozuka2, Konosuke Iwamoto2, Hirono Ito2, Yuji Kawase2, Ryuta Sato2, Toshiki Fujioka2, Yo Araki2, Shigeji Baba2, Yasuo Iwasaki21Department of Neurology, Methodist Neurological Institute, Houston, TX, USA; 2Department of Neurology, Toho University Omori Medical C...
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Dove Medical Press
2009
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oai:doaj.org-article:3b0f1bb172eb465f8aefe58e958193982021-12-02T03:18:03ZBeneficial effect of pramipexole for motor function and depression in Parkinson’s disease1176-63281178-2021https://doaj.org/article/3b0f1bb172eb465f8aefe58e958193982009-02-01T00:00:00Zhttp://www.dovepress.com/beneficial-effect-of-pramipexole-for-motor-function-and-depression-in--a2868https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Osamu Kano1,2, Ken Ikeda2, Tetsuhito Kiyozuka2, Konosuke Iwamoto2, Hirono Ito2, Yuji Kawase2, Ryuta Sato2, Toshiki Fujioka2, Yo Araki2, Shigeji Baba2, Yasuo Iwasaki21Department of Neurology, Methodist Neurological Institute, Houston, TX, USA; 2Department of Neurology, Toho University Omori Medical Center, Tokyo, JapanAbstract: We examined whether pramipexole (PPX) can influence depressive scale in normal and mild depressive parkinsonian patients. In an open study of PPX as an add-on to L-dopa therapy or single administration, 36 nondemented outpatients with Parkinson’s disease (PD) were entered first. All were in the stage II or III of Hoehn and Yahr scale (H&Y). PPX were started at 0.125 mg/day and daily doses were increased to 1.5 mg/day. At 3 months after PPX treatment, patients were re-evaluated. Hamilton Depression Rating Scale (HAM-D), Unified Parkinson’s Disease Rating Scale III, H&Y stage, and freezing of gait questionnaire were compared in patients before and after PPX treatment. These scores were significantly improved after PPX administration. There were no correlations between HAM-D and those motor functions. We suggest that PPX treatment has antidepressant effects in depressive PD patients and also ameliorates HAM-D score in nondepressive PD patients in addition to motor function.Keywords: Parkinson disease, pramipexole, motor function, depression, antidepressant effect Osamu KanoKen IkedaTetsuhito KiyozukaKonosuke IwamotoHirono Itoet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 707-710 (2009) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Osamu Kano Ken Ikeda Tetsuhito Kiyozuka Konosuke Iwamoto Hirono Ito et al Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
| description |
Osamu Kano1,2, Ken Ikeda2, Tetsuhito Kiyozuka2, Konosuke Iwamoto2, Hirono Ito2, Yuji Kawase2, Ryuta Sato2, Toshiki Fujioka2, Yo Araki2, Shigeji Baba2, Yasuo Iwasaki21Department of Neurology, Methodist Neurological Institute, Houston, TX, USA; 2Department of Neurology, Toho University Omori Medical Center, Tokyo, JapanAbstract: We examined whether pramipexole (PPX) can influence depressive scale in normal and mild depressive parkinsonian patients. In an open study of PPX as an add-on to L-dopa therapy or single administration, 36 nondemented outpatients with Parkinson’s disease (PD) were entered first. All were in the stage II or III of Hoehn and Yahr scale (H&Y). PPX were started at 0.125 mg/day and daily doses were increased to 1.5 mg/day. At 3 months after PPX treatment, patients were re-evaluated. Hamilton Depression Rating Scale (HAM-D), Unified Parkinson’s Disease Rating Scale III, H&Y stage, and freezing of gait questionnaire were compared in patients before and after PPX treatment. These scores were significantly improved after PPX administration. There were no correlations between HAM-D and those motor functions. We suggest that PPX treatment has antidepressant effects in depressive PD patients and also ameliorates HAM-D score in nondepressive PD patients in addition to motor function.Keywords: Parkinson disease, pramipexole, motor function, depression, antidepressant effect |
| format |
article |
| author |
Osamu Kano Ken Ikeda Tetsuhito Kiyozuka Konosuke Iwamoto Hirono Ito et al |
| author_facet |
Osamu Kano Ken Ikeda Tetsuhito Kiyozuka Konosuke Iwamoto Hirono Ito et al |
| author_sort |
Osamu Kano |
| title |
Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
| title_short |
Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
| title_full |
Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
| title_fullStr |
Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
| title_full_unstemmed |
Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
| title_sort |
beneficial effect of pramipexole for motor function and depression in parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/3b0f1bb172eb465f8aefe58e95819398 |
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