Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule-associated protein Ase1 for spindle bipolarity.

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Autores principales:	Sergio A. Rincon, Adam Lamson, Robert Blackwell, Viktoriya Syrovatkina, Vincent Fraisier, Anne Paoletti, Meredith D. Betterton, Phong T. Tran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b127b7dd92a4f5f9b7a152eeacecd7f
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spelling	oai:doaj.org-article:3b127b7dd92a4f5f9b7a152eeacecd7f2021-12-02T14:42:45ZKinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast10.1038/ncomms152862041-1723https://doaj.org/article/3b127b7dd92a4f5f9b7a152eeacecd7f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15286https://doaj.org/toc/2041-1723Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule-associated protein Ase1 for spindle bipolarity.Sergio A. RinconAdam LamsonRobert BlackwellViktoriya SyrovatkinaVincent FraisierAnne PaolettiMeredith D. BettertonPhong T. TranNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sergio A. Rincon Adam Lamson Robert Blackwell Viktoriya Syrovatkina Vincent Fraisier Anne Paoletti Meredith D. Betterton Phong T. Tran Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
description	Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule-associated protein Ase1 for spindle bipolarity.
format	article
author	Sergio A. Rincon Adam Lamson Robert Blackwell Viktoriya Syrovatkina Vincent Fraisier Anne Paoletti Meredith D. Betterton Phong T. Tran
author_facet	Sergio A. Rincon Adam Lamson Robert Blackwell Viktoriya Syrovatkina Vincent Fraisier Anne Paoletti Meredith D. Betterton Phong T. Tran
author_sort	Sergio A. Rincon
title	Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
title_short	Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
title_full	Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
title_fullStr	Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
title_full_unstemmed	Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
title_sort	kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker ase1 in fission yeast
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b127b7dd92a4f5f9b7a152eeacecd7f
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Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

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