Molecular Diagnosis of TB in the HIV Positive Population

Background: <a title="Learn more about Tuberculosis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tuberculosis">Tuberculosis</a> (TB) remains a major contributor to <a title="Learn more about Morbidity" href="https://www.scienced...

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Autores principales:	Amy Y. Vittor, Joseph M. Garland, Robert H. Gilman
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2015
Materias:	drug susceptibility testing HIV molecular diagnostics RNA transcription signatures tuberculosis Xpert MTB/RIF Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/3b142330a8d24f9d9ad5620bbdacf8bb
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spelling	oai:doaj.org-article:3b142330a8d24f9d9ad5620bbdacf8bb2021-12-02T07:41:16ZMolecular Diagnosis of TB in the HIV Positive Population2214-999610.1016/j.aogh.2015.01.001https://doaj.org/article/3b142330a8d24f9d9ad5620bbdacf8bb2015-05-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2087https://doaj.org/toc/2214-9996Background: <a title="Learn more about Tuberculosis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tuberculosis">Tuberculosis</a> (TB) remains a major contributor to <a title="Learn more about Morbidity" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/morbidity">morbidity</a> and mortality in HIV-positive individuals, causing 1.1 million incident cases and 0.32 million deaths in 2012. Diagnosis of TB is particularly challenging in HIV-coinfected individuals, due to a high frequency of smear-negative disease, atypical presentations, and extrapulmonary TB. Objective: The aim of this article was to review the current literature on <a title="Learn more about Molecular diagnostics" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/molecular-diagnostics">molecular diagnostics</a> for TB with an emphasis on the performance of these diagnostic tests in the HIV-positive population. Methods: We searched the PubMed database using at least one of the terms TB, <a title="Learn more about Human Immunodeficiency Virus" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/human-immunodeficiency-virus">HIV</a>, diagnostics, Xpert MTB/RIF, '<a title="Learn more about Nucleic acid test" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/nucleic-acid-test">nucleic acid amplification tests</a>', drug susceptibility testing, <a title="Learn more about RNA Transcription" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/rna-transcription">RNA transcription</a>, and drew on World Health Organization publications. Findings: With increased focus on reducing TB prevalence worldwide, a new set of tools for diagnosing the disease have emerged. Molecular tools such as Xpert MTB/RIF and line-probe assays are now in use or are being rolled out in many regions. The diagnostic performance of these and other molecular assays are discussed here as they pertain to the HIV-positive population. Conclusions</h3>Molecular diagnostics offer a useful addition and at times, alternative, to traditional culture methods for the diagnosis of TB. However, most of these tests suffer from decreased accuracy in the HIV-positive population.Amy Y. VittorJoseph M. GarlandRobert H. GilmanUbiquity Pressarticledrug susceptibility testingHIVmolecular diagnosticsRNA transcription signaturestuberculosisXpert MTB/RIFInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 80, Iss 6, Pp 476-485 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug susceptibility testing HIV molecular diagnostics RNA transcription signatures tuberculosis Xpert MTB/RIF Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	drug susceptibility testing HIV molecular diagnostics RNA transcription signatures tuberculosis Xpert MTB/RIF Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Amy Y. Vittor Joseph M. Garland Robert H. Gilman Molecular Diagnosis of TB in the HIV Positive Population
description	Background: <a title="Learn more about Tuberculosis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tuberculosis">Tuberculosis</a> (TB) remains a major contributor to <a title="Learn more about Morbidity" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/morbidity">morbidity</a> and mortality in HIV-positive individuals, causing 1.1 million incident cases and 0.32 million deaths in 2012. Diagnosis of TB is particularly challenging in HIV-coinfected individuals, due to a high frequency of smear-negative disease, atypical presentations, and extrapulmonary TB. Objective: The aim of this article was to review the current literature on <a title="Learn more about Molecular diagnostics" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/molecular-diagnostics">molecular diagnostics</a> for TB with an emphasis on the performance of these diagnostic tests in the HIV-positive population. Methods: We searched the PubMed database using at least one of the terms TB, <a title="Learn more about Human Immunodeficiency Virus" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/human-immunodeficiency-virus">HIV</a>, diagnostics, Xpert MTB/RIF, '<a title="Learn more about Nucleic acid test" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/nucleic-acid-test">nucleic acid amplification tests</a>', drug susceptibility testing, <a title="Learn more about RNA Transcription" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/rna-transcription">RNA transcription</a>, and drew on World Health Organization publications. Findings: With increased focus on reducing TB prevalence worldwide, a new set of tools for diagnosing the disease have emerged. Molecular tools such as Xpert MTB/RIF and line-probe assays are now in use or are being rolled out in many regions. The diagnostic performance of these and other molecular assays are discussed here as they pertain to the HIV-positive population. Conclusions</h3>Molecular diagnostics offer a useful addition and at times, alternative, to traditional culture methods for the diagnosis of TB. However, most of these tests suffer from decreased accuracy in the HIV-positive population.
format	article
author	Amy Y. Vittor Joseph M. Garland Robert H. Gilman
author_facet	Amy Y. Vittor Joseph M. Garland Robert H. Gilman
author_sort	Amy Y. Vittor
title	Molecular Diagnosis of TB in the HIV Positive Population
title_short	Molecular Diagnosis of TB in the HIV Positive Population
title_full	Molecular Diagnosis of TB in the HIV Positive Population
title_fullStr	Molecular Diagnosis of TB in the HIV Positive Population
title_full_unstemmed	Molecular Diagnosis of TB in the HIV Positive Population
title_sort	molecular diagnosis of tb in the hiv positive population
publisher	Ubiquity Press
publishDate	2015
url	https://doaj.org/article/3b142330a8d24f9d9ad5620bbdacf8bb
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Molecular Diagnosis of TB in the HIV Positive Population

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