Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores
In this study, we evaluated the applicability of various superoxide anion sensors which were designed based on either redox or non-redox mechanisms. Firstly, both redox- and non–redox-based superoxide anion probes were designed and synthesized using either coumarin or chromone as the fluorophores, a...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:3b191ad2a0a846fdb014bcf2bf9c73232021-12-01T14:28:55ZInsights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores2296-264610.3389/fchem.2021.753621https://doaj.org/article/3b191ad2a0a846fdb014bcf2bf9c73232021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.753621/fullhttps://doaj.org/toc/2296-2646In this study, we evaluated the applicability of various superoxide anion sensors which were designed based on either redox or non-redox mechanisms. Firstly, both redox- and non–redox-based superoxide anion probes were designed and synthesized using either coumarin or chromone as the fluorophores, and the photophysical properties of these probes were measured. Subsequently, the sensing preference of both types of probes toward various reactive oxygen species (ROS) was evaluated. We found that non–redox-based O2•− probes exhibited broad sensing ability toward various ROS. By contrast, redox based O2•− probes showed a clear reactivity hierarchy which was well correlated to the oxidizing strength of the ROS. Lastly, the detection selectivity of redox-based O2•− recognizing probes was also observed when balancing various factors, such as reactant ROS concentrations, temperature, and changing reaction transformation rates. Herein, we concluded the selectivity advantage of redox-based O2•− probes.Yuchen WangShumi JiaZhenyan YuHui WenHuaqing CuiFrontiers Media S.A.articlecoumarinROSsuperoxide anionredox-based probesnon–redox-based probesselectivityChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021) |
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coumarin ROS superoxide anion redox-based probes non–redox-based probes selectivity Chemistry QD1-999 |
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coumarin ROS superoxide anion redox-based probes non–redox-based probes selectivity Chemistry QD1-999 Yuchen Wang Shumi Jia Zhenyan Yu Hui Wen Huaqing Cui Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores |
| description |
In this study, we evaluated the applicability of various superoxide anion sensors which were designed based on either redox or non-redox mechanisms. Firstly, both redox- and non–redox-based superoxide anion probes were designed and synthesized using either coumarin or chromone as the fluorophores, and the photophysical properties of these probes were measured. Subsequently, the sensing preference of both types of probes toward various reactive oxygen species (ROS) was evaluated. We found that non–redox-based O2•− probes exhibited broad sensing ability toward various ROS. By contrast, redox based O2•− probes showed a clear reactivity hierarchy which was well correlated to the oxidizing strength of the ROS. Lastly, the detection selectivity of redox-based O2•− recognizing probes was also observed when balancing various factors, such as reactant ROS concentrations, temperature, and changing reaction transformation rates. Herein, we concluded the selectivity advantage of redox-based O2•− probes. |
| format |
article |
| author |
Yuchen Wang Shumi Jia Zhenyan Yu Hui Wen Huaqing Cui |
| author_facet |
Yuchen Wang Shumi Jia Zhenyan Yu Hui Wen Huaqing Cui |
| author_sort |
Yuchen Wang |
| title |
Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores |
| title_short |
Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores |
| title_full |
Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores |
| title_fullStr |
Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores |
| title_full_unstemmed |
Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores |
| title_sort |
insights into the detection selectivity of redox and non-redox based probes for the superoxide anion using coumarin and chromone as the fluorophores |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/3b191ad2a0a846fdb014bcf2bf9c7323 |
| work_keys_str_mv |
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1718405050743652352 |