Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins.

<h4>Background</h4>The identification of patients for targeted antineoplastic therapies requires accurate measurement of therapeutic targets and associated signaling complexes. HER3 signaling through heterodimerization is an important growth-promoting mechanism in several tumor types and...

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Autores principales: Ali Mukherjee, Youssouf Badal, Xuan-Thao Nguyen, Johanna Miller, Ahmed Chenna, Hasan Tahir, Alicia Newton, Gordon Parry, Stephen Williams
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/3b1da752ec754496a6e2645d5a96cc18
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