14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ devel...
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2016
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oai:doaj.org-article:3b1e8c0b1da148e8a191c239633cbfee2021-12-02T15:35:19Z14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila10.1038/ncomms115012041-1723https://doaj.org/article/3b1e8c0b1da148e8a191c239633cbfee2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11501https://doaj.org/toc/2041-172314-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ development.Thao Phuong LeLinh Thuong VuongAh-Ram KimYa-Chieh HsuKwang-Wook ChoiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q Thao Phuong Le Linh Thuong Vuong Ah-Ram Kim Ya-Chieh Hsu Kwang-Wook Choi 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila |
description |
14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ development. |
format |
article |
author |
Thao Phuong Le Linh Thuong Vuong Ah-Ram Kim Ya-Chieh Hsu Kwang-Wook Choi |
author_facet |
Thao Phuong Le Linh Thuong Vuong Ah-Ram Kim Ya-Chieh Hsu Kwang-Wook Choi |
author_sort |
Thao Phuong Le |
title |
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila |
title_short |
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila |
title_full |
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila |
title_fullStr |
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila |
title_full_unstemmed |
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila |
title_sort |
14-3-3 proteins regulate tctp–rheb interaction for organ growth in drosophila |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/3b1e8c0b1da148e8a191c239633cbfee |
work_keys_str_mv |
AT thaophuongle 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila AT linhthuongvuong 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila AT ahramkim 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila AT yachiehhsu 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila AT kwangwookchoi 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila |
_version_ |
1718386589161226240 |