Unusual substrate and halide versatility of phenolic halogenase PltM

Halogenase enzymes are of interest as halogenating tools for organic synthesis. Here the authors show that the bacterial FAD-dependent phenolic halogenase PltM chlorinates, brominates and iodinates a variety of substrates and reveal the structural basis for its substrate versatility and provide insi...

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Autores principales:	Shogo Mori, Allan H. Pang, Nishad Thamban Chandrika, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b1f388a92164bef93241673b250f59d
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spelling	oai:doaj.org-article:3b1f388a92164bef93241673b250f59d2021-12-02T16:57:55ZUnusual substrate and halide versatility of phenolic halogenase PltM10.1038/s41467-019-09215-92041-1723https://doaj.org/article/3b1f388a92164bef93241673b250f59d2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09215-9https://doaj.org/toc/2041-1723Halogenase enzymes are of interest as halogenating tools for organic synthesis. Here the authors show that the bacterial FAD-dependent phenolic halogenase PltM chlorinates, brominates and iodinates a variety of substrates and reveal the structural basis for its substrate versatility and provide insights into the FAD recycling mechanism of PltM.Shogo MoriAllan H. PangNishad Thamban ChandrikaSylvie Garneau-TsodikovaOleg V. TsodikovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shogo Mori Allan H. Pang Nishad Thamban Chandrika Sylvie Garneau-Tsodikova Oleg V. Tsodikov Unusual substrate and halide versatility of phenolic halogenase PltM
description	Halogenase enzymes are of interest as halogenating tools for organic synthesis. Here the authors show that the bacterial FAD-dependent phenolic halogenase PltM chlorinates, brominates and iodinates a variety of substrates and reveal the structural basis for its substrate versatility and provide insights into the FAD recycling mechanism of PltM.
format	article
author	Shogo Mori Allan H. Pang Nishad Thamban Chandrika Sylvie Garneau-Tsodikova Oleg V. Tsodikov
author_facet	Shogo Mori Allan H. Pang Nishad Thamban Chandrika Sylvie Garneau-Tsodikova Oleg V. Tsodikov
author_sort	Shogo Mori
title	Unusual substrate and halide versatility of phenolic halogenase PltM
title_short	Unusual substrate and halide versatility of phenolic halogenase PltM
title_full	Unusual substrate and halide versatility of phenolic halogenase PltM
title_fullStr	Unusual substrate and halide versatility of phenolic halogenase PltM
title_full_unstemmed	Unusual substrate and halide versatility of phenolic halogenase PltM
title_sort	unusual substrate and halide versatility of phenolic halogenase pltm
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3b1f388a92164bef93241673b250f59d
work_keys_str_mv	AT shogomori unusualsubstrateandhalideversatilityofphenolichalogenasepltm AT allanhpang unusualsubstrateandhalideversatilityofphenolichalogenasepltm AT nishadthambanchandrika unusualsubstrateandhalideversatilityofphenolichalogenasepltm AT sylviegarneautsodikova unusualsubstrateandhalideversatilityofphenolichalogenasepltm AT olegvtsodikov unusualsubstrateandhalideversatilityofphenolichalogenasepltm
_version_	1718382440585625600

Unusual substrate and halide versatility of phenolic halogenase PltM

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