Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes

Zi-Xian Liao,1 Meng-Chia Liu,1 Ivan M Kempson,2 Yu-Chen Fa,1 Kuo-Yen Huang3,4 1Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 2Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia; 3Institute of Biomedical Sciences...

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Autores principales:	Liao ZX, Liu MC, Kempson IM, Fa YC, Huang KY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	leptin adipocytes differentiation methylcellulose gold nanoparticle degradable hydrogel Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3b203543e374496f9f1096acc9ebda0e
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spelling	oai:doaj.org-article:3b203543e374496f9f1096acc9ebda0e2021-12-02T03:54:16ZLight-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes1178-2013https://doaj.org/article/3b203543e374496f9f1096acc9ebda0e2017-10-01T00:00:00Zhttps://www.dovepress.com/light-triggered-methylcellulose-gold-nanoparticle-hydrogels-for-leptin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zi-Xian Liao,1 Meng-Chia Liu,1 Ivan M Kempson,2 Yu-Chen Fa,1 Kuo-Yen Huang3,4 1Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 2Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia; 3Institute of Biomedical Sciences, Academia Sinica, Taipei, 4Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan Abstract: Leptin is released in response to increased triglyceride storage in adipocytes and impacts body weight, but has drawbacks such as poor therapeutic effect and side effects when delivered systemically. Leptin also modifies adipocyte sensitivity to insulin to inhibit lipid accumulation. Here, light-triggered degradation of hydrogels was used to improve accuracy and effectiveness for sustained and controllable release. In our approach, leptin was entrapped within methylcellulose (MC)-based hydrogels, with incorporation of gold nanoparticles (NP). The incorporation of gold NP into MC hydrogels led to a tunable light irradiation response that dictated the hydrogel release rate of leptin. This manuscript demonstrates feasibility in designing tunable thermosensitive hydrogels for loading multimodality therapeutic agents to enhance the bioactivity of leptin for obesity therapy. Keywords: leptin, adipocytes differentiation, methylcellulose, gold nanoparticle, degradable hydrogelLiao ZXLiu MCKempson IMFa YCHuang KYDove Medical Pressarticleleptinadipocytes differentiationmethylcellulosegold nanoparticledegradable hydrogelMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7603-7611 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin adipocytes differentiation methylcellulose gold nanoparticle degradable hydrogel Medicine (General) R5-920
spellingShingle	leptin adipocytes differentiation methylcellulose gold nanoparticle degradable hydrogel Medicine (General) R5-920 Liao ZX Liu MC Kempson IM Fa YC Huang KY Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
description	Zi-Xian Liao,1 Meng-Chia Liu,1 Ivan M Kempson,2 Yu-Chen Fa,1 Kuo-Yen Huang3,4 1Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 2Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia; 3Institute of Biomedical Sciences, Academia Sinica, Taipei, 4Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan Abstract: Leptin is released in response to increased triglyceride storage in adipocytes and impacts body weight, but has drawbacks such as poor therapeutic effect and side effects when delivered systemically. Leptin also modifies adipocyte sensitivity to insulin to inhibit lipid accumulation. Here, light-triggered degradation of hydrogels was used to improve accuracy and effectiveness for sustained and controllable release. In our approach, leptin was entrapped within methylcellulose (MC)-based hydrogels, with incorporation of gold nanoparticles (NP). The incorporation of gold NP into MC hydrogels led to a tunable light irradiation response that dictated the hydrogel release rate of leptin. This manuscript demonstrates feasibility in designing tunable thermosensitive hydrogels for loading multimodality therapeutic agents to enhance the bioactivity of leptin for obesity therapy. Keywords: leptin, adipocytes differentiation, methylcellulose, gold nanoparticle, degradable hydrogel
format	article
author	Liao ZX Liu MC Kempson IM Fa YC Huang KY
author_facet	Liao ZX Liu MC Kempson IM Fa YC Huang KY
author_sort	Liao ZX
title	Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
title_short	Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
title_full	Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
title_fullStr	Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
title_full_unstemmed	Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
title_sort	light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3b203543e374496f9f1096acc9ebda0e
work_keys_str_mv	AT liaozx lighttriggeredmethylcellulosegoldnanoparticlehydrogelsforleptinreleasetoinhibitfatstoresinadipocytes AT liumc lighttriggeredmethylcellulosegoldnanoparticlehydrogelsforleptinreleasetoinhibitfatstoresinadipocytes AT kempsonim lighttriggeredmethylcellulosegoldnanoparticlehydrogelsforleptinreleasetoinhibitfatstoresinadipocytes AT fayc lighttriggeredmethylcellulosegoldnanoparticlehydrogelsforleptinreleasetoinhibitfatstoresinadipocytes AT huangky lighttriggeredmethylcellulosegoldnanoparticlehydrogelsforleptinreleasetoinhibitfatstoresinadipocytes
_version_	1718401542576406528

Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes

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