Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.

<h4>Purpose</h4>This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.<h4>Methods</h4>The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years)...

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Autores principales:	Corina S Rueegg, Gisela Michel, Laura Wengenroth, Nicolas X von der Weid, Eva Bergstraesser, Claudia E Kuehni, Swiss Paediatric Oncology Group (SPOG)
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b20b15db1c14a8eb778e29e91714219
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spelling	oai:doaj.org-article:3b20b15db1c14a8eb778e29e917142192021-11-18T08:11:35ZPhysical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.1932-620310.1371/journal.pone.0047944https://doaj.org/article/3b20b15db1c14a8eb778e29e917142192012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082232/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.<h4>Methods</h4>The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged <16 years. Siblings received similar questionnaires. We assessed two types of physical performance limitations: 1) limitations in sports; 2) limitations in daily activities (using SF-36 physical function score). We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression.<h4>Results</h4>The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5%) and 7 siblings (1.1%) reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, p<0.001), mainly caused by musculoskeletal and neurological problems. Findings were even more pronounced for children diagnosed more recently (OR 4.8, CI 2.4-9.6 and 8.3, CI 3.7-18.8 for those diagnosed <1990 and ≥ 1990, respectively; p=0.025). Mean physical function score for limitations in daily activities was 49.6 (CI 48.9-50.4) in survivors and 53.1 (CI 52.5-53.7) in siblings (p<0.001). Again, differences tended to be larger in children diagnosed more recently. Survivors of bone tumors, CNS tumors and retinoblastoma and children treated with radiotherapy were most strongly affected.<h4>Conclusion</h4>Survivors of childhood cancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients.Corina S RueeggGisela MichelLaura WengenrothNicolas X von der WeidEva BergstraesserClaudia E KuehniSwiss Paediatric Oncology Group (SPOG)Public Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47944 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Corina S Rueegg Gisela Michel Laura Wengenroth Nicolas X von der Weid Eva Bergstraesser Claudia E Kuehni Swiss Paediatric Oncology Group (SPOG) Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
description	<h4>Purpose</h4>This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.<h4>Methods</h4>The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged <16 years. Siblings received similar questionnaires. We assessed two types of physical performance limitations: 1) limitations in sports; 2) limitations in daily activities (using SF-36 physical function score). We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression.<h4>Results</h4>The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5%) and 7 siblings (1.1%) reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, p<0.001), mainly caused by musculoskeletal and neurological problems. Findings were even more pronounced for children diagnosed more recently (OR 4.8, CI 2.4-9.6 and 8.3, CI 3.7-18.8 for those diagnosed <1990 and ≥ 1990, respectively; p=0.025). Mean physical function score for limitations in daily activities was 49.6 (CI 48.9-50.4) in survivors and 53.1 (CI 52.5-53.7) in siblings (p<0.001). Again, differences tended to be larger in children diagnosed more recently. Survivors of bone tumors, CNS tumors and retinoblastoma and children treated with radiotherapy were most strongly affected.<h4>Conclusion</h4>Survivors of childhood cancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients.
format	article
author	Corina S Rueegg Gisela Michel Laura Wengenroth Nicolas X von der Weid Eva Bergstraesser Claudia E Kuehni Swiss Paediatric Oncology Group (SPOG)
author_facet	Corina S Rueegg Gisela Michel Laura Wengenroth Nicolas X von der Weid Eva Bergstraesser Claudia E Kuehni Swiss Paediatric Oncology Group (SPOG)
author_sort	Corina S Rueegg
title	Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
title_short	Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
title_full	Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
title_fullStr	Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
title_full_unstemmed	Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
title_sort	physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3b20b15db1c14a8eb778e29e91714219
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Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.

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