Epsin and Sla2 form assemblies through phospholipid interfaces

Adapter proteins assist clathrin coated pit assembly. Here, the authors combine native mass spectrometry, crystallography and SAXS measurements and show that the membrane–proximal domains of the adaptor proteins epsin and Sla2 form complexes mediated through phosphatidylinositol 4,5-bisphosphate int...

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Autores principales:	Maria M. Garcia-Alai, Johannes Heidemann, Michal Skruzny, Anna Gieras, Haydyn D. T. Mertens, Dmitri I. Svergun, Marko Kaksonen, Charlotte Uetrecht, Rob Meijers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b231f81fed242b185fa1a34c644ce5f
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id	oai:doaj.org-article:3b231f81fed242b185fa1a34c644ce5f
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spelling	oai:doaj.org-article:3b231f81fed242b185fa1a34c644ce5f2021-12-02T14:39:23ZEpsin and Sla2 form assemblies through phospholipid interfaces10.1038/s41467-017-02443-x2041-1723https://doaj.org/article/3b231f81fed242b185fa1a34c644ce5f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02443-xhttps://doaj.org/toc/2041-1723Adapter proteins assist clathrin coated pit assembly. Here, the authors combine native mass spectrometry, crystallography and SAXS measurements and show that the membrane–proximal domains of the adaptor proteins epsin and Sla2 form complexes mediated through phosphatidylinositol 4,5-bisphosphate interfaces leading to assembly formation.Maria M. Garcia-AlaiJohannes HeidemannMichal SkruznyAnna GierasHaydyn D. T. MertensDmitri I. SvergunMarko KaksonenCharlotte UetrechtRob MeijersNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria M. Garcia-Alai Johannes Heidemann Michal Skruzny Anna Gieras Haydyn D. T. Mertens Dmitri I. Svergun Marko Kaksonen Charlotte Uetrecht Rob Meijers Epsin and Sla2 form assemblies through phospholipid interfaces
description	Adapter proteins assist clathrin coated pit assembly. Here, the authors combine native mass spectrometry, crystallography and SAXS measurements and show that the membrane–proximal domains of the adaptor proteins epsin and Sla2 form complexes mediated through phosphatidylinositol 4,5-bisphosphate interfaces leading to assembly formation.
format	article
author	Maria M. Garcia-Alai Johannes Heidemann Michal Skruzny Anna Gieras Haydyn D. T. Mertens Dmitri I. Svergun Marko Kaksonen Charlotte Uetrecht Rob Meijers
author_facet	Maria M. Garcia-Alai Johannes Heidemann Michal Skruzny Anna Gieras Haydyn D. T. Mertens Dmitri I. Svergun Marko Kaksonen Charlotte Uetrecht Rob Meijers
author_sort	Maria M. Garcia-Alai
title	Epsin and Sla2 form assemblies through phospholipid interfaces
title_short	Epsin and Sla2 form assemblies through phospholipid interfaces
title_full	Epsin and Sla2 form assemblies through phospholipid interfaces
title_fullStr	Epsin and Sla2 form assemblies through phospholipid interfaces
title_full_unstemmed	Epsin and Sla2 form assemblies through phospholipid interfaces
title_sort	epsin and sla2 form assemblies through phospholipid interfaces
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3b231f81fed242b185fa1a34c644ce5f
work_keys_str_mv	AT mariamgarciaalai epsinandsla2formassembliesthroughphospholipidinterfaces AT johannesheidemann epsinandsla2formassembliesthroughphospholipidinterfaces AT michalskruzny epsinandsla2formassembliesthroughphospholipidinterfaces AT annagieras epsinandsla2formassembliesthroughphospholipidinterfaces AT haydyndtmertens epsinandsla2formassembliesthroughphospholipidinterfaces AT dmitriisvergun epsinandsla2formassembliesthroughphospholipidinterfaces AT markokaksonen epsinandsla2formassembliesthroughphospholipidinterfaces AT charlotteuetrecht epsinandsla2formassembliesthroughphospholipidinterfaces AT robmeijers epsinandsla2formassembliesthroughphospholipidinterfaces
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Epsin and Sla2 form assemblies through phospholipid interfaces

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