mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate...

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Autores principales:	Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, Ivan Topisirovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b23e374915e42abafd814b872f5dd1d
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spelling	oai:doaj.org-article:3b23e374915e42abafd814b872f5dd1d2021-12-02T14:38:54ZmTORC1 and CK2 coordinate ternary and eIF4F complex assembly10.1038/ncomms111272041-1723https://doaj.org/article/3b23e374915e42abafd814b872f5dd1d2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11127https://doaj.org/toc/2041-1723Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate cell proliferation.Valentina GandinLaia MasvidalMarie CargnelloLaszlo GyenisShannon McLaughlanYutian CaiClara TenkerianMasahiro MoritaPreetika BalanathanOlivier Jean-JeanVuk StambolicMatthias TrostLuc FuricLouise LaroseAntonis E. KoromilasKatsura AsanoDavid LitchfieldOla LarssonIvan TopisirovicNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Gandin Laia Masvidal Marie Cargnello Laszlo Gyenis Shannon McLaughlan Yutian Cai Clara Tenkerian Masahiro Morita Preetika Balanathan Olivier Jean-Jean Vuk Stambolic Matthias Trost Luc Furic Louise Larose Antonis E. Koromilas Katsura Asano David Litchfield Ola Larsson Ivan Topisirovic mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
description	Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate cell proliferation.
format	article
author	Valentina Gandin Laia Masvidal Marie Cargnello Laszlo Gyenis Shannon McLaughlan Yutian Cai Clara Tenkerian Masahiro Morita Preetika Balanathan Olivier Jean-Jean Vuk Stambolic Matthias Trost Luc Furic Louise Larose Antonis E. Koromilas Katsura Asano David Litchfield Ola Larsson Ivan Topisirovic
author_facet	Valentina Gandin Laia Masvidal Marie Cargnello Laszlo Gyenis Shannon McLaughlan Yutian Cai Clara Tenkerian Masahiro Morita Preetika Balanathan Olivier Jean-Jean Vuk Stambolic Matthias Trost Luc Furic Louise Larose Antonis E. Koromilas Katsura Asano David Litchfield Ola Larsson Ivan Topisirovic
author_sort	Valentina Gandin
title	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_short	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_full	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_fullStr	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_full_unstemmed	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_sort	mtorc1 and ck2 coordinate ternary and eif4f complex assembly
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3b23e374915e42abafd814b872f5dd1d
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mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

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