Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization

Abstract To understand fundamental mechanisms associated with post-flight orthostatic intolerance we investigated the interaction between the cardiovascular and postural functions before and after 60 days of head down bedrest (HDBR). Twenty healthy young males (35.0 ± 1.7 years) were subjected to 60...

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Autores principales:	Da Xu, Malcom F. Tremblay, Ajay K. Verma, Kouhyar Tavakolian, Nandu Goswami, Andrew P. Blaber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b25c8ea1e084610ac60a4e6d5b85d43
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spelling	oai:doaj.org-article:3b25c8ea1e084610ac60a4e6d5b85d432021-12-02T16:26:36ZCardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization10.1038/s41598-020-68962-82045-2322https://doaj.org/article/3b25c8ea1e084610ac60a4e6d5b85d432020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68962-8https://doaj.org/toc/2045-2322Abstract To understand fundamental mechanisms associated with post-flight orthostatic intolerance we investigated the interaction between the cardiovascular and postural functions before and after 60 days of head down bedrest (HDBR). Twenty healthy young males (35.0 ± 1.7 years) were subjected to 60-day HDBR at 6˚ to simulate spaceflight-induced fluid shifts. A supine-to-stand (STS) test was conducted to evaluate cardio-postural control before and after (R) HDBR while an assessment of cardiovascular function was performed during HDBR. Beat-to-beat heart period, systolic blood pressure, and electromyography impulses were derived for wavelet transform coherence and causality analyses of the cardio-postural control and used to assess changes in the muscle-pump baroreflex. During quiet stand of the STS test, compared to baseline, heart rate was 50% higher on the day of exit from bedrest (R0) and 20% higher eight days later (R8). There was a 50% increase in deoxygenated hemoglobin on R0 and R8. Leg muscle activity reduced, and postural sway increased after HDBR. Causality of the muscle-pump baroreflex was reduced on R0 (0.73 ± 0.2) compared to baseline (0.87 ± 0.2) with complete recovery by R8. The muscle-pump baroreflex also had decreased gain and fraction time active following HDBR. Overall, our data show a significantly impaired muscle-pump baroreflex following bedrest.Da XuMalcom F. TremblayAjay K. VermaKouhyar TavakolianNandu GoswamiAndrew P. BlaberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Da Xu Malcom F. Tremblay Ajay K. Verma Kouhyar Tavakolian Nandu Goswami Andrew P. Blaber Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
description	Abstract To understand fundamental mechanisms associated with post-flight orthostatic intolerance we investigated the interaction between the cardiovascular and postural functions before and after 60 days of head down bedrest (HDBR). Twenty healthy young males (35.0 ± 1.7 years) were subjected to 60-day HDBR at 6˚ to simulate spaceflight-induced fluid shifts. A supine-to-stand (STS) test was conducted to evaluate cardio-postural control before and after (R) HDBR while an assessment of cardiovascular function was performed during HDBR. Beat-to-beat heart period, systolic blood pressure, and electromyography impulses were derived for wavelet transform coherence and causality analyses of the cardio-postural control and used to assess changes in the muscle-pump baroreflex. During quiet stand of the STS test, compared to baseline, heart rate was 50% higher on the day of exit from bedrest (R0) and 20% higher eight days later (R8). There was a 50% increase in deoxygenated hemoglobin on R0 and R8. Leg muscle activity reduced, and postural sway increased after HDBR. Causality of the muscle-pump baroreflex was reduced on R0 (0.73 ± 0.2) compared to baseline (0.87 ± 0.2) with complete recovery by R8. The muscle-pump baroreflex also had decreased gain and fraction time active following HDBR. Overall, our data show a significantly impaired muscle-pump baroreflex following bedrest.
format	article
author	Da Xu Malcom F. Tremblay Ajay K. Verma Kouhyar Tavakolian Nandu Goswami Andrew P. Blaber
author_facet	Da Xu Malcom F. Tremblay Ajay K. Verma Kouhyar Tavakolian Nandu Goswami Andrew P. Blaber
author_sort	Da Xu
title	Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
title_short	Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
title_full	Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
title_fullStr	Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
title_full_unstemmed	Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
title_sort	cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3b25c8ea1e084610ac60a4e6d5b85d43
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Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization

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