Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.

Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection against secondary genital tract infection. While it is known that naïve antigen-specific CD4+ T cells can traffic to the genital tract in an antigen-specific manner, these T cells are not protective durin...

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Autores principales:	Jennifer D Helble, Alexander O Mann, Michael N Starnbach
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b25f297cf5f4b73be85007f4f1f8616
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spelling	oai:doaj.org-article:3b25f297cf5f4b73be85007f4f1f86162021-12-02T20:05:45ZAntigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.1932-620310.1371/journal.pone.0240670https://doaj.org/article/3b25f297cf5f4b73be85007f4f1f86162020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0240670https://doaj.org/toc/1932-6203Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection against secondary genital tract infection. While it is known that naïve antigen-specific CD4+ T cells can traffic to the genital tract in an antigen-specific manner, these T cells are not protective during primary infection. Here, we sought to compare the differences between memory and naïve antigen-specific CD4+ T cells in the same mouse following secondary infection using transgenic CD4+ T cells (NR1 T cells). Using RNA sequencing, we found that there were subtle but distinct differences between these two T cell populations. Naïve NR1 T cells significantly upregulated cell cycle genes and were more proliferative than memory NR1 T cells in the draining lymph node. In contrast, memory NR1 T cells were more activated than naïve NR1 T cells and were enriched in the genital tract. Together, our data provide insight into the differences between memory and naïve antigen-specific CD4+ T cells during C. trachomatis infection.Jennifer D HelbleAlexander O MannMichael N StarnbachPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 10, p e0240670 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer D Helble Alexander O Mann Michael N Starnbach Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.
description	Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection against secondary genital tract infection. While it is known that naïve antigen-specific CD4+ T cells can traffic to the genital tract in an antigen-specific manner, these T cells are not protective during primary infection. Here, we sought to compare the differences between memory and naïve antigen-specific CD4+ T cells in the same mouse following secondary infection using transgenic CD4+ T cells (NR1 T cells). Using RNA sequencing, we found that there were subtle but distinct differences between these two T cell populations. Naïve NR1 T cells significantly upregulated cell cycle genes and were more proliferative than memory NR1 T cells in the draining lymph node. In contrast, memory NR1 T cells were more activated than naïve NR1 T cells and were enriched in the genital tract. Together, our data provide insight into the differences between memory and naïve antigen-specific CD4+ T cells during C. trachomatis infection.
format	article
author	Jennifer D Helble Alexander O Mann Michael N Starnbach
author_facet	Jennifer D Helble Alexander O Mann Michael N Starnbach
author_sort	Jennifer D Helble
title	Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.
title_short	Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.
title_full	Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.
title_fullStr	Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.
title_full_unstemmed	Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.
title_sort	antigen-specific memory and naïve cd4+ t cells following secondary chlamydia trachomatis infection.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/3b25f297cf5f4b73be85007f4f1f8616
work_keys_str_mv	AT jenniferdhelble antigenspecificmemoryandnaivecd4tcellsfollowingsecondarychlamydiatrachomatisinfection AT alexanderomann antigenspecificmemoryandnaivecd4tcellsfollowingsecondarychlamydiatrachomatisinfection AT michaelnstarnbach antigenspecificmemoryandnaivecd4tcellsfollowingsecondarychlamydiatrachomatisinfection
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Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.

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