Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells

Mfd recognizes stalled transcriptional complexes at sites of lesions and recruits the nucleotide excision repair proteins (UvrAB) to the site. Here the authors use live cell imaging in E. coli to demonstrate that coordinated ATP hydrolysis by UvrA and loading of UvrB on DNA facilitate the dissociati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Han Ngoc Ho, Antoine M. van Oijen, Harshad Ghodke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b28ffd0a75d46f6afda24c273a72d43
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b28ffd0a75d46f6afda24c273a72d43
record_format	dspace
spelling	oai:doaj.org-article:3b28ffd0a75d46f6afda24c273a72d432021-12-02T15:37:19ZSingle-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells10.1038/s41467-020-15182-32041-1723https://doaj.org/article/3b28ffd0a75d46f6afda24c273a72d432020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15182-3https://doaj.org/toc/2041-1723Mfd recognizes stalled transcriptional complexes at sites of lesions and recruits the nucleotide excision repair proteins (UvrAB) to the site. Here the authors use live cell imaging in E. coli to demonstrate that coordinated ATP hydrolysis by UvrA and loading of UvrB on DNA facilitate the dissociation of Mfd from the handoff complex.Han Ngoc HoAntoine M. van OijenHarshad GhodkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Han Ngoc Ho Antoine M. van Oijen Harshad Ghodke Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
description	Mfd recognizes stalled transcriptional complexes at sites of lesions and recruits the nucleotide excision repair proteins (UvrAB) to the site. Here the authors use live cell imaging in E. coli to demonstrate that coordinated ATP hydrolysis by UvrA and loading of UvrB on DNA facilitate the dissociation of Mfd from the handoff complex.
format	article
author	Han Ngoc Ho Antoine M. van Oijen Harshad Ghodke
author_facet	Han Ngoc Ho Antoine M. van Oijen Harshad Ghodke
author_sort	Han Ngoc Ho
title	Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
title_short	Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
title_full	Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
title_fullStr	Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
title_full_unstemmed	Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
title_sort	single-molecule imaging reveals molecular coupling between transcription and dna repair machinery in live cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3b28ffd0a75d46f6afda24c273a72d43
work_keys_str_mv	AT hanngocho singlemoleculeimagingrevealsmolecularcouplingbetweentranscriptionanddnarepairmachineryinlivecells AT antoinemvanoijen singlemoleculeimagingrevealsmolecularcouplingbetweentranscriptionanddnarepairmachineryinlivecells AT harshadghodke singlemoleculeimagingrevealsmolecularcouplingbetweentranscriptionanddnarepairmachineryinlivecells
_version_	1718386227065913344

Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells

Ejemplares similares