Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature...

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Autores principales:	Wenjing Liao, Libo Zhou, Xiaolong Zhao, Lijuan Song, Yingshen Lu, Nanshan Zhong, Pingchang Yang, Baoqing Sun, Xiaowen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b291b96678e47e0bc98a9609f65d308
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spelling	oai:doaj.org-article:3b291b96678e47e0bc98a9609f65d3082021-12-02T15:05:54ZThermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice10.1038/s41598-017-07471-72045-2322https://doaj.org/article/3b291b96678e47e0bc98a9609f65d3082017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07471-7https://doaj.org/toc/2045-2322Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.Wenjing LiaoLibo ZhouXiaolong ZhaoLijuan SongYingshen LuNanshan ZhongPingchang YangBaoqing SunXiaowen ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenjing Liao Libo Zhou Xiaolong Zhao Lijuan Song Yingshen Lu Nanshan Zhong Pingchang Yang Baoqing Sun Xiaowen Zhang Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
description	Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.
format	article
author	Wenjing Liao Libo Zhou Xiaolong Zhao Lijuan Song Yingshen Lu Nanshan Zhong Pingchang Yang Baoqing Sun Xiaowen Zhang
author_facet	Wenjing Liao Libo Zhou Xiaolong Zhao Lijuan Song Yingshen Lu Nanshan Zhong Pingchang Yang Baoqing Sun Xiaowen Zhang
author_sort	Wenjing Liao
title	Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_short	Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_full	Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_fullStr	Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_full_unstemmed	Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_sort	thermoneutral housing temperature regulates t-regulatory cell function and inhibits ovabumin-induced asthma development in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b291b96678e47e0bc98a9609f65d308
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Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

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