Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening

Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening

Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin opening requires Tpit.

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Detalles Bibliográficos
Autores principales: Alexandre Mayran, Kevin Sochodolsky, Konstantin Khetchoumian, Juliette Harris, Yves Gauthier, Amandine Bemmo, Aurelio Balsalobre, Jacques Drouin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/3b2a61a2cc2044b9be570ebc3124d40d
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