Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid

A group of homochiral quaternary ammonium salts bearing hydrophobic camphoric acid-derived moiety was synthesized and characterized. The aggregation properties of the prepared compounds were evaluated by surface tension measurements, and the critical micelle concentration (CMC) was calculated. The n...

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Autores principales:	Mikláš R., Miklášová N., Bukovský M.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	quaternary ammonium salts antimicrobial activity camphoric acid critical micelle concentration Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3b2c8bbe931f4e03a25a5101d880be96
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spelling	oai:doaj.org-article:3b2c8bbe931f4e03a25a5101d880be962021-12-05T14:11:05ZSynthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid2453-672510.2478/afpuc-2020-0017https://doaj.org/article/3b2c8bbe931f4e03a25a5101d880be962021-04-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2020-0017https://doaj.org/toc/2453-6725A group of homochiral quaternary ammonium salts bearing hydrophobic camphoric acid-derived moiety was synthesized and characterized. The aggregation properties of the prepared compounds were evaluated by surface tension measurements, and the critical micelle concentration (CMC) was calculated. The novel quaternary ammonium bromides were tested as antimicrobial and antifungal agents, and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB). Correlation of MIC with CMC reveals that monomers of prepared cationic surfactants, instead of micelles, are primarily responsible for antimicrobial activity.Mikláš R.Miklášová N.Bukovský M.Sciendoarticlequaternary ammonium saltsantimicrobial activitycamphoric acidcritical micelle concentrationTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 10-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	quaternary ammonium salts antimicrobial activity camphoric acid critical micelle concentration Therapeutics. Pharmacology RM1-950
spellingShingle	quaternary ammonium salts antimicrobial activity camphoric acid critical micelle concentration Therapeutics. Pharmacology RM1-950 Mikláš R. Miklášová N. Bukovský M. Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid
description	A group of homochiral quaternary ammonium salts bearing hydrophobic camphoric acid-derived moiety was synthesized and characterized. The aggregation properties of the prepared compounds were evaluated by surface tension measurements, and the critical micelle concentration (CMC) was calculated. The novel quaternary ammonium bromides were tested as antimicrobial and antifungal agents, and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB). Correlation of MIC with CMC reveals that monomers of prepared cationic surfactants, instead of micelles, are primarily responsible for antimicrobial activity.
format	article
author	Mikláš R. Miklášová N. Bukovský M.
author_facet	Mikláš R. Miklášová N. Bukovský M.
author_sort	Mikláš R.
title	Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid
title_short	Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid
title_full	Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid
title_fullStr	Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid
title_full_unstemmed	Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid
title_sort	synthesis and correlation of aggregation and antimicrobial properties of homochiral quaternary ammonium bromides derived from camphoric acid
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/3b2c8bbe931f4e03a25a5101d880be96
work_keys_str_mv	AT miklasr synthesisandcorrelationofaggregationandantimicrobialpropertiesofhomochiralquaternaryammoniumbromidesderivedfromcamphoricacid AT miklasovan synthesisandcorrelationofaggregationandantimicrobialpropertiesofhomochiralquaternaryammoniumbromidesderivedfromcamphoricacid AT bukovskym synthesisandcorrelationofaggregationandantimicrobialpropertiesofhomochiralquaternaryammoniumbromidesderivedfromcamphoricacid
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Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid

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