EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.

Guardado en:

Detalles Bibliográficos
Autores principales:	Wendy Béguelin, Martín A. Rivas, María T. Calvo Fernández, Matt Teater, Alberto Purwada, David Redmond, Hao Shen, Matt F. Challman, Olivier Elemento, Ankur Singh, Ari M. Melnick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b2ffd3bcb4b423ea05a96db979141c5
record_format	dspace
spelling	oai:doaj.org-article:3b2ffd3bcb4b423ea05a96db979141c52021-12-02T17:06:03ZEZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop10.1038/s41467-017-01029-x2041-1723https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c52017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01029-xhttps://doaj.org/toc/2041-1723The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.Wendy BéguelinMartín A. RivasMaría T. Calvo FernándezMatt TeaterAlberto PurwadaDavid RedmondHao ShenMatt F. ChallmanOlivier ElementoAnkur SinghAri M. MelnickNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wendy Béguelin Martín A. Rivas María T. Calvo Fernández Matt Teater Alberto Purwada David Redmond Hao Shen Matt F. Challman Olivier Elemento Ankur Singh Ari M. Melnick EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
description	The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.
format	article
author	Wendy Béguelin Martín A. Rivas María T. Calvo Fernández Matt Teater Alberto Purwada David Redmond Hao Shen Matt F. Challman Olivier Elemento Ankur Singh Ari M. Melnick
author_facet	Wendy Béguelin Martín A. Rivas María T. Calvo Fernández Matt Teater Alberto Purwada David Redmond Hao Shen Matt F. Challman Olivier Elemento Ankur Singh Ari M. Melnick
author_sort	Wendy Béguelin
title	EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
title_short	EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
title_full	EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
title_fullStr	EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
title_full_unstemmed	EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
title_sort	ezh2 enables germinal centre formation through epigenetic silencing of cdkn1a and an rb-e2f1 feedback loop
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c5
work_keys_str_mv	AT wendybeguelin ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT martinarivas ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT mariatcalvofernandez ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT mattteater ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT albertopurwada ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT davidredmond ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT haoshen ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT mattfchallman ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT olivierelemento ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT ankursingh ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop AT arimmelnick ezh2enablesgerminalcentreformationthroughepigeneticsilencingofcdkn1aandanrbe2f1feedbackloop
_version_	1718381723856666624

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

Ejemplares similares