Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group

In the course of pregnancy, increasing importance is being placed on maintaining optimal fatty acid (FA) levels and particularly n-3 PUFAs to ensure correct fetal development. However, reference ranges for FA have been reported in only a few studies. Our objective is to provide quantitative referenc...

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Autores principales:	Carla Martín-Grau, Ramón Deulofeu, Nuria Serrat Orus, Victoria Arija, on behalf of the ECLIPSES Study Group
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	individual c14-c24 fatty acid status maternal nutrition pregnancy reference intervals Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3b33374a169c4fb380fbe7e63d17bbb0
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spelling	oai:doaj.org-article:3b33374a169c4fb380fbe7e63d17bbb02021-11-25T18:36:17ZTrimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group10.3390/nu131140372072-6643https://doaj.org/article/3b33374a169c4fb380fbe7e63d17bbb02021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4037https://doaj.org/toc/2072-6643In the course of pregnancy, increasing importance is being placed on maintaining optimal fatty acid (FA) levels and particularly n-3 PUFAs to ensure correct fetal development. However, reference ranges for FA have been reported in only a few studies. Our objective is to provide quantitative reference intervals for SFAs, MUFAs, and PUFAs (n-6 and n-3) in a large population of healthy pregnant women from a developed country. A prospective study of pregnant women (<i>n</i> = 479) was conducted from the first trimester (T1) to the third trimester (T3). A total of 11 fatty acids were analyzed in serum by gas chromatography mass spectrometry and were expressed as absolute (µmol/L) and relative (percentage of total FA) concentration units. Serum concentrations of SFAs, MUFAs, n-6 PUFAs, n-3 PUFAs, various FA ratios, and the EFA index were determined. The reference intervals (2.5/97.5 percentiles) in absolute values from T1 ranged from 1884.32 to 8802.81 µmol/L for SFAs, from 959.91 to 2979.46 µmol/L for MUFAs, from 2325.77 to 7735.74 µmol/L for n-6 PUFAs, and from 129.01 to 495.58 µmol/L for n-3 PUFAs. These intervals mainly include the values of other studies from European populations. However, reference ranges vary according to some maternal factors. The FA levels proposed, obtained from a large sample of pregnant women, will be a useful tool for assessing the degree of adequacy of FAs in pregnant women and will help to carry out dietary interventions based on certain maternal factors.Carla Martín-GrauRamón DeulofeuNuria Serrat OrusVictoria Arijaon behalf of the ECLIPSES Study GroupMDPI AGarticleindividual c14-c24fatty acid statusmaternal nutritionpregnancyreference intervalsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4037, p 4037 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	individual c14-c24 fatty acid status maternal nutrition pregnancy reference intervals Nutrition. Foods and food supply TX341-641
spellingShingle	individual c14-c24 fatty acid status maternal nutrition pregnancy reference intervals Nutrition. Foods and food supply TX341-641 Carla Martín-Grau Ramón Deulofeu Nuria Serrat Orus Victoria Arija on behalf of the ECLIPSES Study Group Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group
description	In the course of pregnancy, increasing importance is being placed on maintaining optimal fatty acid (FA) levels and particularly n-3 PUFAs to ensure correct fetal development. However, reference ranges for FA have been reported in only a few studies. Our objective is to provide quantitative reference intervals for SFAs, MUFAs, and PUFAs (n-6 and n-3) in a large population of healthy pregnant women from a developed country. A prospective study of pregnant women (<i>n</i> = 479) was conducted from the first trimester (T1) to the third trimester (T3). A total of 11 fatty acids were analyzed in serum by gas chromatography mass spectrometry and were expressed as absolute (µmol/L) and relative (percentage of total FA) concentration units. Serum concentrations of SFAs, MUFAs, n-6 PUFAs, n-3 PUFAs, various FA ratios, and the EFA index were determined. The reference intervals (2.5/97.5 percentiles) in absolute values from T1 ranged from 1884.32 to 8802.81 µmol/L for SFAs, from 959.91 to 2979.46 µmol/L for MUFAs, from 2325.77 to 7735.74 µmol/L for n-6 PUFAs, and from 129.01 to 495.58 µmol/L for n-3 PUFAs. These intervals mainly include the values of other studies from European populations. However, reference ranges vary according to some maternal factors. The FA levels proposed, obtained from a large sample of pregnant women, will be a useful tool for assessing the degree of adequacy of FAs in pregnant women and will help to carry out dietary interventions based on certain maternal factors.
format	article
author	Carla Martín-Grau Ramón Deulofeu Nuria Serrat Orus Victoria Arija on behalf of the ECLIPSES Study Group
author_facet	Carla Martín-Grau Ramón Deulofeu Nuria Serrat Orus Victoria Arija on behalf of the ECLIPSES Study Group
author_sort	Carla Martín-Grau
title	Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group
title_short	Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group
title_full	Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group
title_fullStr	Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group
title_full_unstemmed	Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group
title_sort	trimester-specific reference ranges for saturated, monounsaturated and polyunsaturated fatty acids in serum of pregnant women: a cohort study from the eclipses group
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3b33374a169c4fb380fbe7e63d17bbb0
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Trimester-Specific Reference Ranges for Saturated, Monounsaturated and Polyunsaturated Fatty Acids in Serum of Pregnant Women: A Cohort Study from the ECLIPSES Group

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