The middle lipin domain adopts a membrane-binding dimeric protein fold

Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for membrane binding and full functionality of lipins.

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Autores principales:	Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b33c35036634db9ae0d9e4f5089b84e
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spelling	oai:doaj.org-article:3b33c35036634db9ae0d9e4f5089b84e2021-12-02T18:49:17ZThe middle lipin domain adopts a membrane-binding dimeric protein fold10.1038/s41467-021-24929-52041-1723https://doaj.org/article/3b33c35036634db9ae0d9e4f5089b84e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24929-5https://doaj.org/toc/2041-1723Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for membrane binding and full functionality of lipins.Weijing GuShujuan GaoHuan WangKaelin D. FlemingReece M. HoffmannJong Won YangNimi M. PatelYong Mi ChoiJohn E. BurkeKaren ReueMichael V. AirolaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weijing Gu Shujuan Gao Huan Wang Kaelin D. Fleming Reece M. Hoffmann Jong Won Yang Nimi M. Patel Yong Mi Choi John E. Burke Karen Reue Michael V. Airola The middle lipin domain adopts a membrane-binding dimeric protein fold
description	Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for membrane binding and full functionality of lipins.
format	article
author	Weijing Gu Shujuan Gao Huan Wang Kaelin D. Fleming Reece M. Hoffmann Jong Won Yang Nimi M. Patel Yong Mi Choi John E. Burke Karen Reue Michael V. Airola
author_facet	Weijing Gu Shujuan Gao Huan Wang Kaelin D. Fleming Reece M. Hoffmann Jong Won Yang Nimi M. Patel Yong Mi Choi John E. Burke Karen Reue Michael V. Airola
author_sort	Weijing Gu
title	The middle lipin domain adopts a membrane-binding dimeric protein fold
title_short	The middle lipin domain adopts a membrane-binding dimeric protein fold
title_full	The middle lipin domain adopts a membrane-binding dimeric protein fold
title_fullStr	The middle lipin domain adopts a membrane-binding dimeric protein fold
title_full_unstemmed	The middle lipin domain adopts a membrane-binding dimeric protein fold
title_sort	middle lipin domain adopts a membrane-binding dimeric protein fold
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b33c35036634db9ae0d9e4f5089b84e
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The middle lipin domain adopts a membrane-binding dimeric protein fold

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