Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period
Abstract Preterm very low birth weight infants (VLBWi) are known to be at greater risk of adverse neurodevelopmental outcome. Identifying early factors associated with outcome is essential in order to refer patients for early intervention. Few studies have investigated neurodevelopmental outcome in...
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Nature Portfolio
2021
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oai:doaj.org-article:3b38fc613a9d4004abbf0a1df7e8f7ac2021-12-02T15:07:54ZNeurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period10.1038/s41598-021-95864-02045-2322https://doaj.org/article/3b38fc613a9d4004abbf0a1df7e8f7ac2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95864-0https://doaj.org/toc/2045-2322Abstract Preterm very low birth weight infants (VLBWi) are known to be at greater risk of adverse neurodevelopmental outcome. Identifying early factors associated with outcome is essential in order to refer patients for early intervention. Few studies have investigated neurodevelopmental outcome in Italian VLBWi. The aim of our longitudinal study is to describe neurodevelopmental outcome at 24 months of corrected age in an eleven-year cohort of 502 Italian preterm VLBWi and to identify associations with outcome. At 24 months, Griffiths’ Mental Developmental Scales were administered. Neurodevelopmental outcome was classified as: normal, minor sequelae (minor neurological signs, General Quotient between 76 and 87), major sequelae (cerebral palsy; General Quotient ≤ 75; severe sensory impairment). 75.3% showed a normal outcome, 13.9% minor sequelae and 10.8% major sequelae (3.8% cerebral palsy). Male gender, bronchopulmonary dysplasia, abnormal neonatal neurological assessment and severe brain ultrasound abnormalities were independently associated with poor outcome on multivariate ordered logistic regression. Rates of major sequelae are in line with international studies, as is the prevalence of developmental delay over cerebral palsy. Analysis of perinatal complications and the combination of close cUS monitoring and neurological assessment are still essential for early identification of infants with adverse outcome.Stefania LongoCamilla CaporaliCamilla PisoniAlessandro BorghesiGianfranco PerottiGiovanna TrittoIvana OlivieriRoberta La PianaDavide TondutiAlice DecioGiada AriaudoSilvia SpairaniCecilia NaboniBarbara GardellaArsenio SpinilloFederica ManzoniCarmine TinelliMauro StronatiSimona OrcesiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Stefania Longo Camilla Caporali Camilla Pisoni Alessandro Borghesi Gianfranco Perotti Giovanna Tritto Ivana Olivieri Roberta La Piana Davide Tonduti Alice Decio Giada Ariaudo Silvia Spairani Cecilia Naboni Barbara Gardella Arsenio Spinillo Federica Manzoni Carmine Tinelli Mauro Stronati Simona Orcesi Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period |
| description |
Abstract Preterm very low birth weight infants (VLBWi) are known to be at greater risk of adverse neurodevelopmental outcome. Identifying early factors associated with outcome is essential in order to refer patients for early intervention. Few studies have investigated neurodevelopmental outcome in Italian VLBWi. The aim of our longitudinal study is to describe neurodevelopmental outcome at 24 months of corrected age in an eleven-year cohort of 502 Italian preterm VLBWi and to identify associations with outcome. At 24 months, Griffiths’ Mental Developmental Scales were administered. Neurodevelopmental outcome was classified as: normal, minor sequelae (minor neurological signs, General Quotient between 76 and 87), major sequelae (cerebral palsy; General Quotient ≤ 75; severe sensory impairment). 75.3% showed a normal outcome, 13.9% minor sequelae and 10.8% major sequelae (3.8% cerebral palsy). Male gender, bronchopulmonary dysplasia, abnormal neonatal neurological assessment and severe brain ultrasound abnormalities were independently associated with poor outcome on multivariate ordered logistic regression. Rates of major sequelae are in line with international studies, as is the prevalence of developmental delay over cerebral palsy. Analysis of perinatal complications and the combination of close cUS monitoring and neurological assessment are still essential for early identification of infants with adverse outcome. |
| format |
article |
| author |
Stefania Longo Camilla Caporali Camilla Pisoni Alessandro Borghesi Gianfranco Perotti Giovanna Tritto Ivana Olivieri Roberta La Piana Davide Tonduti Alice Decio Giada Ariaudo Silvia Spairani Cecilia Naboni Barbara Gardella Arsenio Spinillo Federica Manzoni Carmine Tinelli Mauro Stronati Simona Orcesi |
| author_facet |
Stefania Longo Camilla Caporali Camilla Pisoni Alessandro Borghesi Gianfranco Perotti Giovanna Tritto Ivana Olivieri Roberta La Piana Davide Tonduti Alice Decio Giada Ariaudo Silvia Spairani Cecilia Naboni Barbara Gardella Arsenio Spinillo Federica Manzoni Carmine Tinelli Mauro Stronati Simona Orcesi |
| author_sort |
Stefania Longo |
| title |
Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period |
| title_short |
Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period |
| title_full |
Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period |
| title_fullStr |
Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period |
| title_full_unstemmed |
Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period |
| title_sort |
neurodevelopmental outcome of preterm very low birth weight infants admitted to an italian tertiary center over an 11-year period |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3b38fc613a9d4004abbf0a1df7e8f7ac |
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