Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a
SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.
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Nature Portfolio
2020
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oai:doaj.org-article:3b3910c818a141759af3688133b306052021-12-02T14:41:26ZModulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a10.1038/s41467-019-13851-62041-1723https://doaj.org/article/3b3910c818a141759af3688133b306052020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13851-6https://doaj.org/toc/2041-1723SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.Jinwei ZhangMohammad Iqbal H. BhuiyanTing ZhangJason K. KarimyZhijuan WuVictoria M. FieslerJingfang ZhangHuachen HuangMd Nabiul HasanAnna E. SkrzypiecMariusz MuchaDaniel DuranWei HuangRobert PawlakLesley M. FoleyT. Kevin HitchensMargaret B. MinnighSamuel M. PoloyacSeth L. AlperBradley J. MolyneauxAndrew J. TrevelyanKristopher T. KahleDandan SunXianming DengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jinwei Zhang Mohammad Iqbal H. Bhuiyan Ting Zhang Jason K. Karimy Zhijuan Wu Victoria M. Fiesler Jingfang Zhang Huachen Huang Md Nabiul Hasan Anna E. Skrzypiec Mariusz Mucha Daniel Duran Wei Huang Robert Pawlak Lesley M. Foley T. Kevin Hitchens Margaret B. Minnigh Samuel M. Poloyac Seth L. Alper Bradley J. Molyneaux Andrew J. Trevelyan Kristopher T. Kahle Dandan Sun Xianming Deng Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a |
| description |
SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models. |
| format |
article |
| author |
Jinwei Zhang Mohammad Iqbal H. Bhuiyan Ting Zhang Jason K. Karimy Zhijuan Wu Victoria M. Fiesler Jingfang Zhang Huachen Huang Md Nabiul Hasan Anna E. Skrzypiec Mariusz Mucha Daniel Duran Wei Huang Robert Pawlak Lesley M. Foley T. Kevin Hitchens Margaret B. Minnigh Samuel M. Poloyac Seth L. Alper Bradley J. Molyneaux Andrew J. Trevelyan Kristopher T. Kahle Dandan Sun Xianming Deng |
| author_facet |
Jinwei Zhang Mohammad Iqbal H. Bhuiyan Ting Zhang Jason K. Karimy Zhijuan Wu Victoria M. Fiesler Jingfang Zhang Huachen Huang Md Nabiul Hasan Anna E. Skrzypiec Mariusz Mucha Daniel Duran Wei Huang Robert Pawlak Lesley M. Foley T. Kevin Hitchens Margaret B. Minnigh Samuel M. Poloyac Seth L. Alper Bradley J. Molyneaux Andrew J. Trevelyan Kristopher T. Kahle Dandan Sun Xianming Deng |
| author_sort |
Jinwei Zhang |
| title |
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a |
| title_short |
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a |
| title_full |
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a |
| title_fullStr |
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a |
| title_full_unstemmed |
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a |
| title_sort |
modulation of brain cation-cl− cotransport via the spak kinase inhibitor zt-1a |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/3b3910c818a141759af3688133b30605 |
| work_keys_str_mv |
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