Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.

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Autores principales: Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Jingfang Zhang, Huachen Huang, Md Nabiul Hasan, Anna E. Skrzypiec, Mariusz Mucha, Daniel Duran, Wei Huang, Robert Pawlak, Lesley M. Foley, T. Kevin Hitchens, Margaret B. Minnigh, Samuel M. Poloyac, Seth L. Alper, Bradley J. Molyneaux, Andrew J. Trevelyan, Kristopher T. Kahle, Dandan Sun, Xianming Deng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/3b3910c818a141759af3688133b30605
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