Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic

A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania...

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Autores principales:	Daniela Pițigoi, Oana Săndulescu, Maria Dorina Crăciun, Anca Drăgănescu, Gheorghiță Jugulete, Anca Streinu-Cercel, Angelica Vișan, Claudia Rîciu, Alexandru Rafila, Victoria Aramă, Monica Luminos, Adrian Streinu-Cercel
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	measles vaccination vaccine-preventable disease measles epidemic Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/3b3a1c0027a14d8080740d404372ddd0
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spelling	oai:doaj.org-article:3b3a1c0027a14d8080740d404372ddd02021-11-17T14:21:58ZMeasles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic2150-55942150-560810.1080/21505594.2020.1771948https://doaj.org/article/3b3a1c0027a14d8080740d404372ddd02020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1771948https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania during the first three years of the current measles epidemic (July 2016–July 2019). More than half of the patients (57.6%) had ages below 5 years; 6% (n = 82) had preexisting comorbidities. Only 1.5% of the patients had been fully vaccinated, 5.9% had received only one vaccine dose, while 92.8% had not been vaccinated at all against measles. The rate of measles-related complications was 93.4%; complications occurred more frequently among patients who were not eligible for vaccination due to young age or underlying diseases, and among children, who developed pneumonia and enterocolitis more frequently than adults. The median hospital length-of-stay was 6 days. Eight cases (0.6%) required intensive care and mechanical ventilation, and three deaths (0.2%) were recorded. Measles disproportionately affects patient groups who are not eligible for vaccination. During the current epidemic in Romania, 98.5% of the patients hospitalized for measles had not been vaccinated and among these, 75.7% would have been eligible for vaccination. For the remaining pool of unvaccinated children, supplementary immunization activities are urgently needed.Daniela PițigoiOana SăndulescuMaria Dorina CrăciunAnca DrăgănescuGheorghiță JuguleteAnca Streinu-CercelAngelica VișanClaudia RîciuAlexandru RafilaVictoria AramăMonica LuminosAdrian Streinu-CercelTaylor & Francis Grouparticlemeaslesvaccinationvaccine-preventable diseasemeasles epidemicInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 686-694 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	measles vaccination vaccine-preventable disease measles epidemic Infectious and parasitic diseases RC109-216
spellingShingle	measles vaccination vaccine-preventable disease measles epidemic Infectious and parasitic diseases RC109-216 Daniela Pițigoi Oana Săndulescu Maria Dorina Crăciun Anca Drăgănescu Gheorghiță Jugulete Anca Streinu-Cercel Angelica Vișan Claudia Rîciu Alexandru Rafila Victoria Aramă Monica Luminos Adrian Streinu-Cercel Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
description	A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania during the first three years of the current measles epidemic (July 2016–July 2019). More than half of the patients (57.6%) had ages below 5 years; 6% (n = 82) had preexisting comorbidities. Only 1.5% of the patients had been fully vaccinated, 5.9% had received only one vaccine dose, while 92.8% had not been vaccinated at all against measles. The rate of measles-related complications was 93.4%; complications occurred more frequently among patients who were not eligible for vaccination due to young age or underlying diseases, and among children, who developed pneumonia and enterocolitis more frequently than adults. The median hospital length-of-stay was 6 days. Eight cases (0.6%) required intensive care and mechanical ventilation, and three deaths (0.2%) were recorded. Measles disproportionately affects patient groups who are not eligible for vaccination. During the current epidemic in Romania, 98.5% of the patients hospitalized for measles had not been vaccinated and among these, 75.7% would have been eligible for vaccination. For the remaining pool of unvaccinated children, supplementary immunization activities are urgently needed.
format	article
author	Daniela Pițigoi Oana Săndulescu Maria Dorina Crăciun Anca Drăgănescu Gheorghiță Jugulete Anca Streinu-Cercel Angelica Vișan Claudia Rîciu Alexandru Rafila Victoria Aramă Monica Luminos Adrian Streinu-Cercel
author_facet	Daniela Pițigoi Oana Săndulescu Maria Dorina Crăciun Anca Drăgănescu Gheorghiță Jugulete Anca Streinu-Cercel Angelica Vișan Claudia Rîciu Alexandru Rafila Victoria Aramă Monica Luminos Adrian Streinu-Cercel
author_sort	Daniela Pițigoi
title	Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_short	Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_full	Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_fullStr	Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_full_unstemmed	Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_sort	measles in romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/3b3a1c0027a14d8080740d404372ddd0
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Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic

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