Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of AC...

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Autores principales: Changhai Lei, Kewen Qian, Tian Li, Sheng Zhang, Wenyan Fu, Min Ding, Shi Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3b3d05e197724b28bed5fc76756f4d1d
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spelling oai:doaj.org-article:3b3d05e197724b28bed5fc76756f4d1d2021-12-02T16:49:45ZNeutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig10.1038/s41467-020-16048-42041-1723https://doaj.org/article/3b3d05e197724b28bed5fc76756f4d1d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16048-4https://doaj.org/toc/2041-1723SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice.Changhai LeiKewen QianTian LiSheng ZhangWenyan FuMin DingShi HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Changhai Lei
Kewen Qian
Tian Li
Sheng Zhang
Wenyan Fu
Min Ding
Shi Hu
Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
description SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice.
format article
author Changhai Lei
Kewen Qian
Tian Li
Sheng Zhang
Wenyan Fu
Min Ding
Shi Hu
author_facet Changhai Lei
Kewen Qian
Tian Li
Sheng Zhang
Wenyan Fu
Min Ding
Shi Hu
author_sort Changhai Lei
title Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
title_short Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
title_full Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
title_fullStr Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
title_full_unstemmed Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
title_sort neutralization of sars-cov-2 spike pseudotyped virus by recombinant ace2-ig
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3b3d05e197724b28bed5fc76756f4d1d
work_keys_str_mv AT changhailei neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
AT kewenqian neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
AT tianli neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
AT shengzhang neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
AT wenyanfu neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
AT minding neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
AT shihu neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig
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