Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy

Hai Zhu,1 Binwei Zhou,2 Leung Chan,2 Yanxin Du,1 Tianfeng Chen1 1Department of Internal Medicine and Orthopedics, Guangdong Provincial Hospital of Traditional Chinese Medicine, 2Department of Chemistry, Jinan University, Guangzhou, China Abstract: Rational design and construction of delivery nanos...

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Autores principales:	Zhu H, Zhou B, Chan L, Du Y, Chen T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	cancer targeting nanographene oxide nanomedicine transferrin platinum complex cell apoptosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3b3e321b03c0417586eba3ff70844e04
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spelling	oai:doaj.org-article:3b3e321b03c0417586eba3ff70844e042021-12-02T01:04:04ZTransferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy1178-2013https://doaj.org/article/3b3e321b03c0417586eba3ff70844e042017-07-01T00:00:00Zhttps://www.dovepress.com/transferrin-functionalized-nanographene-oxide-for-delivery-of-platinum-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hai Zhu,1 Binwei Zhou,2 Leung Chan,2 Yanxin Du,1 Tianfeng Chen1 1Department of Internal Medicine and Orthopedics, Guangdong Provincial Hospital of Traditional Chinese Medicine, 2Department of Chemistry, Jinan University, Guangzhou, China Abstract: Rational design and construction of delivery nanosystems for anticancer metal complexes is a crucial strategy to improve solubility under physiological conditions and permeability and retention behavior in tumor cells. Therefore, in this study, we designed and synthesize a transferrin (Tf)-conjugated nanographene oxide (NGO) nanosystem as a cancer-targeted nanocarrier of Pt complexes (Tf-NGO@Pt). This nanodelivery system exhibited good solubility under physiological conditions. Moreover, Tf-NGO@Pt showed higher anticancer efficacy against MCF human breast cancer cells than the free Pt complex, and effectively inhibited cancer-cell migration and invasion, with involvement of reactive oxygen species overproduction. In addition, nanolization also enhanced the penetration ability and inhibitory effect of the Pt complex toward MCF7 breast cancer-cell tumor spheroids. The enhancement of anticancer efficacy was positively correlated with increased cellular uptake and cellular drug retention. This study provides a new strategy to facilitate the future application of metal complexes in cancer therapy. Keywords: cancer targeting, nanographene oxide, nanomedicine, transferrin, platinum complex, cell apoptosisZhu HZhou BChan LDu YChen TDove Medical Pressarticlecancer targetingnanographene oxide nanomedicinetransferrinplatinum complexcell apoptosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5023-5038 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer targeting nanographene oxide nanomedicine transferrin platinum complex cell apoptosis Medicine (General) R5-920
spellingShingle	cancer targeting nanographene oxide nanomedicine transferrin platinum complex cell apoptosis Medicine (General) R5-920 Zhu H Zhou B Chan L Du Y Chen T Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
description	Hai Zhu,1 Binwei Zhou,2 Leung Chan,2 Yanxin Du,1 Tianfeng Chen1 1Department of Internal Medicine and Orthopedics, Guangdong Provincial Hospital of Traditional Chinese Medicine, 2Department of Chemistry, Jinan University, Guangzhou, China Abstract: Rational design and construction of delivery nanosystems for anticancer metal complexes is a crucial strategy to improve solubility under physiological conditions and permeability and retention behavior in tumor cells. Therefore, in this study, we designed and synthesize a transferrin (Tf)-conjugated nanographene oxide (NGO) nanosystem as a cancer-targeted nanocarrier of Pt complexes (Tf-NGO@Pt). This nanodelivery system exhibited good solubility under physiological conditions. Moreover, Tf-NGO@Pt showed higher anticancer efficacy against MCF human breast cancer cells than the free Pt complex, and effectively inhibited cancer-cell migration and invasion, with involvement of reactive oxygen species overproduction. In addition, nanolization also enhanced the penetration ability and inhibitory effect of the Pt complex toward MCF7 breast cancer-cell tumor spheroids. The enhancement of anticancer efficacy was positively correlated with increased cellular uptake and cellular drug retention. This study provides a new strategy to facilitate the future application of metal complexes in cancer therapy. Keywords: cancer targeting, nanographene oxide, nanomedicine, transferrin, platinum complex, cell apoptosis
format	article
author	Zhu H Zhou B Chan L Du Y Chen T
author_facet	Zhu H Zhou B Chan L Du Y Chen T
author_sort	Zhu H
title	Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
title_short	Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
title_full	Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
title_fullStr	Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
title_full_unstemmed	Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
title_sort	transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3b3e321b03c0417586eba3ff70844e04
work_keys_str_mv	AT zhuh transferrinfunctionalizednanographeneoxidefordeliveryofplatinumcomplexestoenhancecancercellselectivityandapoptosisinducingefficacy AT zhoub transferrinfunctionalizednanographeneoxidefordeliveryofplatinumcomplexestoenhancecancercellselectivityandapoptosisinducingefficacy AT chanl transferrinfunctionalizednanographeneoxidefordeliveryofplatinumcomplexestoenhancecancercellselectivityandapoptosisinducingefficacy AT duy transferrinfunctionalizednanographeneoxidefordeliveryofplatinumcomplexestoenhancecancercellselectivityandapoptosisinducingefficacy AT chent transferrinfunctionalizednanographeneoxidefordeliveryofplatinumcomplexestoenhancecancercellselectivityandapoptosisinducingefficacy
_version_	1718403309599981568

Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy

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