Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Abstract Background This study aims to determine and compare the effects of exercise modalities with different intensities on the secretion of key inflammation and hypoxia markers in amateur athletes. Methods Twenty-three athletes with a mean age of 20.1 years, living at low altitude (1850 m) partic...

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Autores principales:	Fatih Baygutalp, Yusuf Buzdağlı, Murat Ozan, Mitat Koz, Nurcan Kılıç Baygutalp, Gökhan Atasever
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Anti-inflammatory cytokine Exercise Health Hypoxia Pro-inflammatory cytokine Sports medicine RC1200-1245
Acceso en línea:	https://doaj.org/article/3b4bb828a7084d69945538a991bf6d86
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spelling	oai:doaj.org-article:3b4bb828a7084d69945538a991bf6d862021-11-28T12:37:56ZImpacts of different intensities of exercise on inflammation and hypoxia markers in low altitude10.1186/s13102-021-00375-02052-1847https://doaj.org/article/3b4bb828a7084d69945538a991bf6d862021-11-01T00:00:00Zhttps://doi.org/10.1186/s13102-021-00375-0https://doaj.org/toc/2052-1847Abstract Background This study aims to determine and compare the effects of exercise modalities with different intensities on the secretion of key inflammation and hypoxia markers in amateur athletes. Methods Twenty-three athletes with a mean age of 20.1 years, living at low altitude (1850 m) participated in this study. The participants' maximal oxygen consumption values (VO2 max) were determined with an incremental cycle exercise test as 54.15 ± 6.14 mL kg min−1. Athletes performed four protocols: at rest, 50% VO2 max, 75% VO2 max and 100% VO2 max (until exhaustion) with one-week intervals. 50% VO2 max, 75% VO2 max sessions were performed continuously for 30 min on a bicycle ergometer and 100% VO2 max session was performed by cycling until exhaustion. Blood samples were obtained at rest and immediately after each exercise session. Serum tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), interleukin-10 (IL-10), and hypoxia inducible factor-1 alpha (HIF-1α) levels were measured. Results There were significant differences in serum TNF-α levels in 75% VO2 max and 100% VO2 max sessions (489.03 ± 368.37 and 472.70 ± 365.21 ng/L, respectively) compared to rest conditions (331.65 ± 293.52 ng/L). Serum CRP levels of 50% VO2 max and 75% VO2 max sessions (1.19 ± 0.50; 1.07 ± 0.52 mg/L) were significantly higher than the rest condition (0.74 ± 0.35 mg/L). There were significant differences in serum IL-10 levels of rest condition and 50% VO2 max; 50% VO2 max, and 100% VO2 max sessions (328.09 ± 128.87; 446.36 ± 142.84; 347.44 ± 135.69; 324.88 ± 168.06 pg/mL). Serum HIF-1α levels were significantly higher in 75% VO2 max session compared to rest (1.26 ± 0.16; 1.08 ± 0.19 ng/mL) (P < 0.05 for all comparisons). Conclusions Both inflammatory and anti-inflammatory pathway is induced on different exercise intensities. Exercise protocols performed until exhaustion may lead to activation of inflammatory pathways and hypoxia-induced damage.Fatih BaygutalpYusuf BuzdağlıMurat OzanMitat KozNurcan Kılıç BaygutalpGökhan AtaseverBMCarticleAnti-inflammatory cytokineExerciseHealthHypoxiaPro-inflammatory cytokineSports medicineRC1200-1245ENBMC Sports Science, Medicine and Rehabilitation, Vol 13, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anti-inflammatory cytokine Exercise Health Hypoxia Pro-inflammatory cytokine Sports medicine RC1200-1245
spellingShingle	Anti-inflammatory cytokine Exercise Health Hypoxia Pro-inflammatory cytokine Sports medicine RC1200-1245 Fatih Baygutalp Yusuf Buzdağlı Murat Ozan Mitat Koz Nurcan Kılıç Baygutalp Gökhan Atasever Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
description	Abstract Background This study aims to determine and compare the effects of exercise modalities with different intensities on the secretion of key inflammation and hypoxia markers in amateur athletes. Methods Twenty-three athletes with a mean age of 20.1 years, living at low altitude (1850 m) participated in this study. The participants' maximal oxygen consumption values (VO2 max) were determined with an incremental cycle exercise test as 54.15 ± 6.14 mL kg min−1. Athletes performed four protocols: at rest, 50% VO2 max, 75% VO2 max and 100% VO2 max (until exhaustion) with one-week intervals. 50% VO2 max, 75% VO2 max sessions were performed continuously for 30 min on a bicycle ergometer and 100% VO2 max session was performed by cycling until exhaustion. Blood samples were obtained at rest and immediately after each exercise session. Serum tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), interleukin-10 (IL-10), and hypoxia inducible factor-1 alpha (HIF-1α) levels were measured. Results There were significant differences in serum TNF-α levels in 75% VO2 max and 100% VO2 max sessions (489.03 ± 368.37 and 472.70 ± 365.21 ng/L, respectively) compared to rest conditions (331.65 ± 293.52 ng/L). Serum CRP levels of 50% VO2 max and 75% VO2 max sessions (1.19 ± 0.50; 1.07 ± 0.52 mg/L) were significantly higher than the rest condition (0.74 ± 0.35 mg/L). There were significant differences in serum IL-10 levels of rest condition and 50% VO2 max; 50% VO2 max, and 100% VO2 max sessions (328.09 ± 128.87; 446.36 ± 142.84; 347.44 ± 135.69; 324.88 ± 168.06 pg/mL). Serum HIF-1α levels were significantly higher in 75% VO2 max session compared to rest (1.26 ± 0.16; 1.08 ± 0.19 ng/mL) (P < 0.05 for all comparisons). Conclusions Both inflammatory and anti-inflammatory pathway is induced on different exercise intensities. Exercise protocols performed until exhaustion may lead to activation of inflammatory pathways and hypoxia-induced damage.
format	article
author	Fatih Baygutalp Yusuf Buzdağlı Murat Ozan Mitat Koz Nurcan Kılıç Baygutalp Gökhan Atasever
author_facet	Fatih Baygutalp Yusuf Buzdağlı Murat Ozan Mitat Koz Nurcan Kılıç Baygutalp Gökhan Atasever
author_sort	Fatih Baygutalp
title	Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
title_short	Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
title_full	Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
title_fullStr	Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
title_full_unstemmed	Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
title_sort	impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3b4bb828a7084d69945538a991bf6d86
work_keys_str_mv	AT fatihbaygutalp impactsofdifferentintensitiesofexerciseoninflammationandhypoxiamarkersinlowaltitude AT yusufbuzdaglı impactsofdifferentintensitiesofexerciseoninflammationandhypoxiamarkersinlowaltitude AT muratozan impactsofdifferentintensitiesofexerciseoninflammationandhypoxiamarkersinlowaltitude AT mitatkoz impactsofdifferentintensitiesofexerciseoninflammationandhypoxiamarkersinlowaltitude AT nurcankılıcbaygutalp impactsofdifferentintensitiesofexerciseoninflammationandhypoxiamarkersinlowaltitude AT gokhanatasever impactsofdifferentintensitiesofexerciseoninflammationandhypoxiamarkersinlowaltitude
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Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

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