Oxidation-specific epitopes restrain bone formation

Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced...

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Auteurs principaux:	Elena Ambrogini, Xuchu Que, Shuling Wang, Fumihiro Yamaguchi, Robert S. Weinstein, Sotirios Tsimikas, Stavros C. Manolagas, Joseph L. Witztum, Robert L. Jilka
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd6
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spelling	oai:doaj.org-article:3b5383334d33469ca0d3bacfa1e40cd62021-12-02T15:33:37ZOxidation-specific epitopes restrain bone formation10.1038/s41467-018-04047-52041-1723https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd62018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04047-5https://doaj.org/toc/2041-1723Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced by high-fat diet and have increased bone mass when fed a normal diet, and that levels of innate antibodies to OSEs decrease with ageing.Elena AmbroginiXuchu QueShuling WangFumihiro YamaguchiRobert S. WeinsteinSotirios TsimikasStavros C. ManolagasJoseph L. WitztumRobert L. JilkaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elena Ambrogini Xuchu Que Shuling Wang Fumihiro Yamaguchi Robert S. Weinstein Sotirios Tsimikas Stavros C. Manolagas Joseph L. Witztum Robert L. Jilka Oxidation-specific epitopes restrain bone formation
description	Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced by high-fat diet and have increased bone mass when fed a normal diet, and that levels of innate antibodies to OSEs decrease with ageing.
format	article
author	Elena Ambrogini Xuchu Que Shuling Wang Fumihiro Yamaguchi Robert S. Weinstein Sotirios Tsimikas Stavros C. Manolagas Joseph L. Witztum Robert L. Jilka
author_facet	Elena Ambrogini Xuchu Que Shuling Wang Fumihiro Yamaguchi Robert S. Weinstein Sotirios Tsimikas Stavros C. Manolagas Joseph L. Witztum Robert L. Jilka
author_sort	Elena Ambrogini
title	Oxidation-specific epitopes restrain bone formation
title_short	Oxidation-specific epitopes restrain bone formation
title_full	Oxidation-specific epitopes restrain bone formation
title_fullStr	Oxidation-specific epitopes restrain bone formation
title_full_unstemmed	Oxidation-specific epitopes restrain bone formation
title_sort	oxidation-specific epitopes restrain bone formation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd6
work_keys_str_mv	AT elenaambrogini oxidationspecificepitopesrestrainboneformation AT xuchuque oxidationspecificepitopesrestrainboneformation AT shulingwang oxidationspecificepitopesrestrainboneformation AT fumihiroyamaguchi oxidationspecificepitopesrestrainboneformation AT robertsweinstein oxidationspecificepitopesrestrainboneformation AT sotiriostsimikas oxidationspecificepitopesrestrainboneformation AT stavroscmanolagas oxidationspecificepitopesrestrainboneformation AT josephlwitztum oxidationspecificepitopesrestrainboneformation AT robertljilka oxidationspecificepitopesrestrainboneformation
_version_	1718387076120969216

Oxidation-specific epitopes restrain bone formation

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