Oxidation-specific epitopes restrain bone formation
Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced...
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Auteurs principaux: | Elena Ambrogini, Xuchu Que, Shuling Wang, Fumihiro Yamaguchi, Robert S. Weinstein, Sotirios Tsimikas, Stavros C. Manolagas, Joseph L. Witztum, Robert L. Jilka |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
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Sujets: | |
Accès en ligne: | https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd6 |
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