Oxidation-specific epitopes restrain bone formation

Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced...

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Autores principales: Elena Ambrogini, Xuchu Que, Shuling Wang, Fumihiro Yamaguchi, Robert S. Weinstein, Sotirios Tsimikas, Stavros C. Manolagas, Joseph L. Witztum, Robert L. Jilka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd6
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