Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhiyong Xu, Chunyi Guo, Qiaoli Ye, Yueli Shi, Yihui Sun, Jie Zhang, Jiaqi Huang, Yizhou Huang, Chunlai Zeng, Xue Zhang, Yuehai Ke, Hongqiang Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b558ae5e336405a9be16f4647d6437b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b558ae5e336405a9be16f4647d6437b
record_format	dspace
spelling	oai:doaj.org-article:3b558ae5e336405a9be16f4647d6437b2021-11-08T11:11:22ZEndothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization10.1038/s41467-021-26697-82041-1723https://doaj.org/article/3b558ae5e336405a9be16f4647d6437b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26697-8https://doaj.org/toc/2041-1723SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.Zhiyong XuChunyi GuoQiaoli YeYueli ShiYihui SunJie ZhangJiaqi HuangYizhou HuangChunlai ZengXue ZhangYuehai KeHongqiang ChengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiyong Xu Chunyi Guo Qiaoli Ye Yueli Shi Yihui Sun Jie Zhang Jiaqi Huang Yizhou Huang Chunlai Zeng Xue Zhang Yuehai Ke Hongqiang Cheng Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
description	SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.
format	article
author	Zhiyong Xu Chunyi Guo Qiaoli Ye Yueli Shi Yihui Sun Jie Zhang Jiaqi Huang Yizhou Huang Chunlai Zeng Xue Zhang Yuehai Ke Hongqiang Cheng
author_facet	Zhiyong Xu Chunyi Guo Qiaoli Ye Yueli Shi Yihui Sun Jie Zhang Jiaqi Huang Yizhou Huang Chunlai Zeng Xue Zhang Yuehai Ke Hongqiang Cheng
author_sort	Zhiyong Xu
title	Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
title_short	Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
title_full	Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
title_fullStr	Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
title_full_unstemmed	Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
title_sort	endothelial deletion of shp2 suppresses tumor angiogenesis and promotes vascular normalization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b558ae5e336405a9be16f4647d6437b
work_keys_str_mv	AT zhiyongxu endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT chunyiguo endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT qiaoliye endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT yuelishi endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT yihuisun endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT jiezhang endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT jiaqihuang endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT yizhouhuang endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT chunlaizeng endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT xuezhang endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT yuehaike endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization AT hongqiangcheng endothelialdeletionofshp2suppressestumorangiogenesisandpromotesvascularnormalization
_version_	1718442322616647680

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

Ejemplares similares