Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.

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Autores principales: Zhiyong Xu, Chunyi Guo, Qiaoli Ye, Yueli Shi, Yihui Sun, Jie Zhang, Jiaqi Huang, Yizhou Huang, Chunlai Zeng, Xue Zhang, Yuehai Ke, Hongqiang Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3b558ae5e336405a9be16f4647d6437b
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