Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that stabilizes the viral capsid and regulates infe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chuang Liu, Juan R. Perilla, Jiying Ning, Manman Lu, Guangjin Hou, Ruben Ramalho, Benjamin A. Himes, Gongpu Zhao, Gregory J. Bedwell, In-Ja Byeon, Jinwoo Ahn, Angela M. Gronenborn, Peter E. Prevelige, Itay Rousso, Christopher Aiken, Tatyana Polenova, Klaus Schulten, Peijun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b563f433dd146d4b7f6b78da7c03c54
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3b563f433dd146d4b7f6b78da7c03c54
record_format	dspace
spelling	oai:doaj.org-article:3b563f433dd146d4b7f6b78da7c03c542021-12-02T17:31:18ZCyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site10.1038/ncomms107142041-1723https://doaj.org/article/3b563f433dd146d4b7f6b78da7c03c542016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10714https://doaj.org/toc/2041-1723The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that stabilizes the viral capsid and regulates infectivity.Chuang LiuJuan R. PerillaJiying NingManman LuGuangjin HouRuben RamalhoBenjamin A. HimesGongpu ZhaoGregory J. BedwellIn-Ja ByeonJinwoo AhnAngela M. GronenbornPeter E. PreveligeItay RoussoChristopher AikenTatyana PolenovaKlaus SchultenPeijun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuang Liu Juan R. Perilla Jiying Ning Manman Lu Guangjin Hou Ruben Ramalho Benjamin A. Himes Gongpu Zhao Gregory J. Bedwell In-Ja Byeon Jinwoo Ahn Angela M. Gronenborn Peter E. Prevelige Itay Rousso Christopher Aiken Tatyana Polenova Klaus Schulten Peijun Zhang Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
description	The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that stabilizes the viral capsid and regulates infectivity.
format	article
author	Chuang Liu Juan R. Perilla Jiying Ning Manman Lu Guangjin Hou Ruben Ramalho Benjamin A. Himes Gongpu Zhao Gregory J. Bedwell In-Ja Byeon Jinwoo Ahn Angela M. Gronenborn Peter E. Prevelige Itay Rousso Christopher Aiken Tatyana Polenova Klaus Schulten Peijun Zhang
author_facet	Chuang Liu Juan R. Perilla Jiying Ning Manman Lu Guangjin Hou Ruben Ramalho Benjamin A. Himes Gongpu Zhao Gregory J. Bedwell In-Ja Byeon Jinwoo Ahn Angela M. Gronenborn Peter E. Prevelige Itay Rousso Christopher Aiken Tatyana Polenova Klaus Schulten Peijun Zhang
author_sort	Chuang Liu
title	Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
title_short	Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
title_full	Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
title_fullStr	Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
title_full_unstemmed	Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
title_sort	cyclophilin a stabilizes the hiv-1 capsid through a novel non-canonical binding site
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3b563f433dd146d4b7f6b78da7c03c54
work_keys_str_mv	AT chuangliu cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT juanrperilla cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT jiyingning cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT manmanlu cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT guangjinhou cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT rubenramalho cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT benjaminahimes cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT gongpuzhao cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT gregoryjbedwell cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT injabyeon cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT jinwooahn cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT angelamgronenborn cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT petereprevelige cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT itayrousso cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT christopheraiken cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT tatyanapolenova cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT klausschulten cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite AT peijunzhang cyclophilinastabilizesthehiv1capsidthroughanovelnoncanonicalbindingsite
_version_	1718380667619770368

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

Ejemplares similares