Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research

Carbon ion radiotherapy (CIRT) is a useful and advanced technique for prostate cancer. This study sought to investigate the clinical efficacy and translational research for prostate cancer with carbon ion radiotherapy. We integrated the data from published articles, clinical trials websites, and our...

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Autores principales: Xue Chen, Qi Yu, Ping Li, Shen Fu
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/3b567b448b4045bd9d7ebbeae082162b
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spelling oai:doaj.org-article:3b567b448b4045bd9d7ebbeae082162b2021-11-05T12:34:13ZLandscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research2234-943X10.3389/fonc.2021.760752https://doaj.org/article/3b567b448b4045bd9d7ebbeae082162b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.760752/fullhttps://doaj.org/toc/2234-943XCarbon ion radiotherapy (CIRT) is a useful and advanced technique for prostate cancer. This study sought to investigate the clinical efficacy and translational research for prostate cancer with carbon ion radiotherapy. We integrated the data from published articles, clinical trials websites, and our data. The efficacy of CIRT for prostate cancer was assessed in terms of overall survival, biochemical recurrence-free survival, and toxicity response. Up to now, clinical treatment of carbon ion radiotherapy has been carried in only five countries. We found that carbon ion radiotherapy induced little genitourinary and gastrointestinal toxicity when used for prostate cancer treatment. To some extent, it led to improved outcomes in overall survival, biochemical recurrence-free survival than conventional radiotherapy, especially for high-risk prostate cancer. Carbon ion radiotherapy brought clinical benefits for prostate cancer patients, and quality of life assessment indicated that CIRT affected patients to a lesser extent. Potential biomarkers from our omics-based study could be used to predict the efficacy of prostate cancer with CIRT. Carbon ion radiotherapy brought clinical benefits for prostate cancer patients. The omics-based translational research may provide insights into individualized therapy.Xue ChenXue ChenQi YuQi YuQi YuQi YuPing LiShen FuShen FuShen FuShen FuShen FuFrontiers Media S.A.articlecarbon ion radiotherapyefficacyprostate cancerquality of lifetranslational researchNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution DOAJ
collection DOAJ
language EN
topic carbon ion radiotherapy
efficacy
prostate cancer
quality of life
translational research
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle carbon ion radiotherapy
efficacy
prostate cancer
quality of life
translational research
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Xue Chen
Xue Chen
Qi Yu
Qi Yu
Qi Yu
Qi Yu
Ping Li
Shen Fu
Shen Fu
Shen Fu
Shen Fu
Shen Fu
Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research
description Carbon ion radiotherapy (CIRT) is a useful and advanced technique for prostate cancer. This study sought to investigate the clinical efficacy and translational research for prostate cancer with carbon ion radiotherapy. We integrated the data from published articles, clinical trials websites, and our data. The efficacy of CIRT for prostate cancer was assessed in terms of overall survival, biochemical recurrence-free survival, and toxicity response. Up to now, clinical treatment of carbon ion radiotherapy has been carried in only five countries. We found that carbon ion radiotherapy induced little genitourinary and gastrointestinal toxicity when used for prostate cancer treatment. To some extent, it led to improved outcomes in overall survival, biochemical recurrence-free survival than conventional radiotherapy, especially for high-risk prostate cancer. Carbon ion radiotherapy brought clinical benefits for prostate cancer patients, and quality of life assessment indicated that CIRT affected patients to a lesser extent. Potential biomarkers from our omics-based study could be used to predict the efficacy of prostate cancer with CIRT. Carbon ion radiotherapy brought clinical benefits for prostate cancer patients. The omics-based translational research may provide insights into individualized therapy.
format article
author Xue Chen
Xue Chen
Qi Yu
Qi Yu
Qi Yu
Qi Yu
Ping Li
Shen Fu
Shen Fu
Shen Fu
Shen Fu
Shen Fu
author_facet Xue Chen
Xue Chen
Qi Yu
Qi Yu
Qi Yu
Qi Yu
Ping Li
Shen Fu
Shen Fu
Shen Fu
Shen Fu
Shen Fu
author_sort Xue Chen
title Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research
title_short Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research
title_full Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research
title_fullStr Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research
title_full_unstemmed Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research
title_sort landscape of carbon ion radiotherapy in prostate cancer: clinical application and translational research
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/3b567b448b4045bd9d7ebbeae082162b
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