CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and in...

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Autores principales: Yuhong Chen, Mei Yu, Yongwei Zheng, Guoping Fu, Gang Xin, Wen Zhu, Lan Luo, Robert Burns, Quan-Zhen Li, Alexander L. Dent, Nan Zhu, Weiguo Cui, Laurent Malherbe, Renren Wen, Demin Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3b58b83ee76b4ab8925812d290639692
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Sumario:B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and induces concomitant production of autoantibodies.

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