CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and in...

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Autores principales:	Yuhong Chen, Mei Yu, Yongwei Zheng, Guoping Fu, Gang Xin, Wen Zhu, Lan Luo, Robert Burns, Quan-Zhen Li, Alexander L. Dent, Nan Zhu, Weiguo Cui, Laurent Malherbe, Renren Wen, Demin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b58b83ee76b4ab8925812d290639692
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spelling	oai:doaj.org-article:3b58b83ee76b4ab8925812d2906396922021-12-02T17:02:12ZCXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance10.1038/s41467-019-12446-52041-1723https://doaj.org/article/3b58b83ee76b4ab8925812d2906396922019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12446-5https://doaj.org/toc/2041-1723B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and induces concomitant production of autoantibodies.Yuhong ChenMei YuYongwei ZhengGuoping FuGang XinWen ZhuLan LuoRobert BurnsQuan-Zhen LiAlexander L. DentNan ZhuWeiguo CuiLaurent MalherbeRenren WenDemin WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L. Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
description	B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and induces concomitant production of autoantibodies.
format	article
author	Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L. Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang
author_facet	Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L. Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang
author_sort	Yuhong Chen
title	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_short	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_full	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_fullStr	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_full_unstemmed	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_sort	cxcr5+pd-1+ follicular helper cd8 t cells control b cell tolerance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3b58b83ee76b4ab8925812d290639692
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CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

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