Do Neurotrophins Connect Neurological Disorders and Heart Diseases?

Neurotrophins (NTs) are one of the most characterized neurotrophic factor family members and consist of four members in mammals. Growing evidence suggests that there is a complex inter- and bi-directional relationship between central nervous system (CNS) disorders and cardiac dysfunction, so-called...

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Autores principales:	Masashi Fujitani, Yoshinori Otani, Hisao Miyajima
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neurotrophins nerve growth factor brain-derived neurotrophic factor tropomyosin-related kinase receptors low-affinity p75 neurotrophin receptor brain–heart axis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3b59aa51d3eb44d2a40bc5488e164fa6
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spelling	oai:doaj.org-article:3b59aa51d3eb44d2a40bc5488e164fa62021-11-25T16:54:34ZDo Neurotrophins Connect Neurological Disorders and Heart Diseases?10.3390/biom111117302218-273Xhttps://doaj.org/article/3b59aa51d3eb44d2a40bc5488e164fa62021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1730https://doaj.org/toc/2218-273XNeurotrophins (NTs) are one of the most characterized neurotrophic factor family members and consist of four members in mammals. Growing evidence suggests that there is a complex inter- and bi-directional relationship between central nervous system (CNS) disorders and cardiac dysfunction, so-called “brain–heart axis”. Recent studies suggest that CNS disorders, including neurodegenerative diseases, stroke, and depression, affect cardiovascular function via various mechanisms, such as hypothalamic–pituitary–adrenal axis augmentation. Although this brain–heart axis has been well studied in humans and mice, the involvement of NT signaling in the axis has not been fully investigated. In the first half of this review, we emphasize the importance of NTs not only in the nervous system, but also in the cardiovascular system from the embryonic stage to the adult state. In the second half, we discuss the involvement of NTs in the pathogenesis of cardiovascular diseases, and then examine whether an alteration in NTs could serve as the mediator between neurological disorders and heart dysfunction. The further investigation we propose herein could contribute to finding direct evidence for the involvement of NTs in the axis and new treatment for cardiovascular diseases.Masashi FujitaniYoshinori OtaniHisao MiyajimaMDPI AGarticleneurotrophinsnerve growth factorbrain-derived neurotrophic factortropomyosin-related kinase receptorslow-affinity p75 neurotrophin receptorbrain–heart axisMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1730, p 1730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurotrophins nerve growth factor brain-derived neurotrophic factor tropomyosin-related kinase receptors low-affinity p75 neurotrophin receptor brain–heart axis Microbiology QR1-502
spellingShingle	neurotrophins nerve growth factor brain-derived neurotrophic factor tropomyosin-related kinase receptors low-affinity p75 neurotrophin receptor brain–heart axis Microbiology QR1-502 Masashi Fujitani Yoshinori Otani Hisao Miyajima Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
description	Neurotrophins (NTs) are one of the most characterized neurotrophic factor family members and consist of four members in mammals. Growing evidence suggests that there is a complex inter- and bi-directional relationship between central nervous system (CNS) disorders and cardiac dysfunction, so-called “brain–heart axis”. Recent studies suggest that CNS disorders, including neurodegenerative diseases, stroke, and depression, affect cardiovascular function via various mechanisms, such as hypothalamic–pituitary–adrenal axis augmentation. Although this brain–heart axis has been well studied in humans and mice, the involvement of NT signaling in the axis has not been fully investigated. In the first half of this review, we emphasize the importance of NTs not only in the nervous system, but also in the cardiovascular system from the embryonic stage to the adult state. In the second half, we discuss the involvement of NTs in the pathogenesis of cardiovascular diseases, and then examine whether an alteration in NTs could serve as the mediator between neurological disorders and heart dysfunction. The further investigation we propose herein could contribute to finding direct evidence for the involvement of NTs in the axis and new treatment for cardiovascular diseases.
format	article
author	Masashi Fujitani Yoshinori Otani Hisao Miyajima
author_facet	Masashi Fujitani Yoshinori Otani Hisao Miyajima
author_sort	Masashi Fujitani
title	Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
title_short	Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
title_full	Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
title_fullStr	Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
title_full_unstemmed	Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
title_sort	do neurotrophins connect neurological disorders and heart diseases?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3b59aa51d3eb44d2a40bc5488e164fa6
work_keys_str_mv	AT masashifujitani doneurotrophinsconnectneurologicaldisordersandheartdiseases AT yoshinoriotani doneurotrophinsconnectneurologicaldisordersandheartdiseases AT hisaomiyajima doneurotrophinsconnectneurologicaldisordersandheartdiseases
_version_	1718412831670403072

Do Neurotrophins Connect Neurological Disorders and Heart Diseases?

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