Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

Axially chiral arylquinazolinones are structural motifs in several natural products and can also act as chiral ligands. Here, the authors show a chiral phosphoric acid-catalysed strategy to access enantiomerically pure arylquinazolinones by efficient transfer of central chirality into axial chiralit...

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Bibliographic Details
Main Authors: Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu, Bin Tan
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/3b59fe05320b44a1be60dbb3f7de7f2f
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Summary:Axially chiral arylquinazolinones are structural motifs in several natural products and can also act as chiral ligands. Here, the authors show a chiral phosphoric acid-catalysed strategy to access enantiomerically pure arylquinazolinones by efficient transfer of central chirality into axial chirality.