DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation

DNMT3A mutations are known to cause acute myeloid leukaemia. Here, Koya et al. show that DNMT3A R882H mutation causes monoblastic transformation and haematopoietic stem cell accumulation in a methylation-independent manner, by suppressing the polycomb repressive complex 1, causing transcriptional si...

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Autores principales:	Junji Koya, Keisuke Kataoka, Tomohiko Sato, Masashige Bando, Yuki Kato, Takako Tsuruta-Kishino, Hiroshi Kobayashi, Kensuke Narukawa, Hiroyuki Miyoshi, Katsuhiko Shirahige, Mineo Kurokawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b5a176a67f947c3b5e27931bbee2280
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spelling	oai:doaj.org-article:3b5a176a67f947c3b5e27931bbee22802021-12-02T16:58:12ZDNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation10.1038/ncomms109242041-1723https://doaj.org/article/3b5a176a67f947c3b5e27931bbee22802016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10924https://doaj.org/toc/2041-1723DNMT3A mutations are known to cause acute myeloid leukaemia. Here, Koya et al. show that DNMT3A R882H mutation causes monoblastic transformation and haematopoietic stem cell accumulation in a methylation-independent manner, by suppressing the polycomb repressive complex 1, causing transcriptional silencing.Junji KoyaKeisuke KataokaTomohiko SatoMasashige BandoYuki KatoTakako Tsuruta-KishinoHiroshi KobayashiKensuke NarukawaHiroyuki MiyoshiKatsuhiko ShirahigeMineo KurokawaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junji Koya Keisuke Kataoka Tomohiko Sato Masashige Bando Yuki Kato Takako Tsuruta-Kishino Hiroshi Kobayashi Kensuke Narukawa Hiroyuki Miyoshi Katsuhiko Shirahige Mineo Kurokawa DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
description	DNMT3A mutations are known to cause acute myeloid leukaemia. Here, Koya et al. show that DNMT3A R882H mutation causes monoblastic transformation and haematopoietic stem cell accumulation in a methylation-independent manner, by suppressing the polycomb repressive complex 1, causing transcriptional silencing.
format	article
author	Junji Koya Keisuke Kataoka Tomohiko Sato Masashige Bando Yuki Kato Takako Tsuruta-Kishino Hiroshi Kobayashi Kensuke Narukawa Hiroyuki Miyoshi Katsuhiko Shirahige Mineo Kurokawa
author_facet	Junji Koya Keisuke Kataoka Tomohiko Sato Masashige Bando Yuki Kato Takako Tsuruta-Kishino Hiroshi Kobayashi Kensuke Narukawa Hiroyuki Miyoshi Katsuhiko Shirahige Mineo Kurokawa
author_sort	Junji Koya
title	DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
title_short	DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
title_full	DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
title_fullStr	DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
title_full_unstemmed	DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
title_sort	dnmt3a r882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3b5a176a67f947c3b5e27931bbee2280
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DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation

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