DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
DNMT3A mutations are known to cause acute myeloid leukaemia. Here, Koya et al. show that DNMT3A R882H mutation causes monoblastic transformation and haematopoietic stem cell accumulation in a methylation-independent manner, by suppressing the polycomb repressive complex 1, causing transcriptional si...
Guardado en:
Autores principales: | Junji Koya, Keisuke Kataoka, Tomohiko Sato, Masashige Bando, Yuki Kato, Takako Tsuruta-Kishino, Hiroshi Kobayashi, Kensuke Narukawa, Hiroyuki Miyoshi, Katsuhiko Shirahige, Mineo Kurokawa |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3b5a176a67f947c3b5e27931bbee2280 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
por: Hiwot Anteneh, et al.
Publicado: (2020) -
Acta Nº882
por: Banco Central de Chile
Publicado: (2019) -
DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma
por: Simona Camero, et al.
Publicado: (2021) -
Dynamics of the Metabolome of <i>Aliinostoc</i> sp. PMC 882.14 in Response to Light and Temperature Variations
por: Damien Le Moigne, et al.
Publicado: (2021) -
Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques
por: Joanna L. Denbigh, et al.
Publicado: (2017)