The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study
Background: Hypersensitivity reactions (HSR)s to platinum agents are increasing in frequency, due to their extensive use and repeated exposures in patients with increased life expectancy. The aims of our study are to analyze the frequency of both type I and type IV HSRs in patients with gynecologica...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3b5a675d8b294e668f62ebf751fc41c9 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3b5a675d8b294e668f62ebf751fc41c9 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3b5a675d8b294e668f62ebf751fc41c92021-11-11T15:33:34ZThe Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study10.3390/cancers132154682072-6694https://doaj.org/article/3b5a675d8b294e668f62ebf751fc41c92021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5468https://doaj.org/toc/2072-6694Background: Hypersensitivity reactions (HSR)s to platinum agents are increasing in frequency, due to their extensive use and repeated exposures in patients with increased life expectancy. The aims of our study are to analyze the frequency of both type I and type IV HSRs in patients with gynecological cancer treated with (CBDCA) carboplatin and/or (CDDP) cisplatin, to evaluate the role of skin tests in the diagnosis and prevention of HSRs. Methods: From 2011 to 2018, we evaluated 124 consecutive female patients previously treated with CBDCA and/or CDDP for gynecological cancer. All patients, including those with and without HSR to previous platinum-based therapy, underwent <i>in-vivo</i> skin tests for platinum agents before starting the second or more therapeutic lines. To reduce the risk of false negative results, patients with a negative skin test at the first evaluation were re-tested after 3 weeks from the platinum re-exposure. Results: Among the 124 patients evaluated, 58 (47%) experienced HSRs to at least one platinum agent: 35% were to CBDCA, 5% to CDDP, 7% to both. Fifty-six of the 58 HSRs were classified as immediate and two delayed. Skin tests confirmed an IgE-dependent mechanism in 67% of patients with immediate-HSRs to CBDCA and identified a cross-reactivity between platinum agents in 18% of patients. Moreover, among those who had never developed an HSRs during platinum-based therapy, <i>in-vivo</i> skin tests identified 12% of sensitized patients. Conclusions: On the basis of our findings, skin test for platinum agents is a simple and sensitive tool for the diagnosis and prevention of HSRs to CBDCA and/or CDDP and can be useful for detecting possible cross-reactivity among platinum agents.Ilaria PuxedduFiorella PetrelliMaria Elena GuerrieriStefania CosioIsabella Del CorsoValeria RocchiMaria Laura MancaPaola MiglioriniAngiolo GadducciMDPI AGarticlegynecological cancercarboplatincisplatinhypersensitivity reactionsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5468, p 5468 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
gynecological cancer carboplatin cisplatin hypersensitivity reactions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
gynecological cancer carboplatin cisplatin hypersensitivity reactions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ilaria Puxeddu Fiorella Petrelli Maria Elena Guerrieri Stefania Cosio Isabella Del Corso Valeria Rocchi Maria Laura Manca Paola Migliorini Angiolo Gadducci The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study |
| description |
Background: Hypersensitivity reactions (HSR)s to platinum agents are increasing in frequency, due to their extensive use and repeated exposures in patients with increased life expectancy. The aims of our study are to analyze the frequency of both type I and type IV HSRs in patients with gynecological cancer treated with (CBDCA) carboplatin and/or (CDDP) cisplatin, to evaluate the role of skin tests in the diagnosis and prevention of HSRs. Methods: From 2011 to 2018, we evaluated 124 consecutive female patients previously treated with CBDCA and/or CDDP for gynecological cancer. All patients, including those with and without HSR to previous platinum-based therapy, underwent <i>in-vivo</i> skin tests for platinum agents before starting the second or more therapeutic lines. To reduce the risk of false negative results, patients with a negative skin test at the first evaluation were re-tested after 3 weeks from the platinum re-exposure. Results: Among the 124 patients evaluated, 58 (47%) experienced HSRs to at least one platinum agent: 35% were to CBDCA, 5% to CDDP, 7% to both. Fifty-six of the 58 HSRs were classified as immediate and two delayed. Skin tests confirmed an IgE-dependent mechanism in 67% of patients with immediate-HSRs to CBDCA and identified a cross-reactivity between platinum agents in 18% of patients. Moreover, among those who had never developed an HSRs during platinum-based therapy, <i>in-vivo</i> skin tests identified 12% of sensitized patients. Conclusions: On the basis of our findings, skin test for platinum agents is a simple and sensitive tool for the diagnosis and prevention of HSRs to CBDCA and/or CDDP and can be useful for detecting possible cross-reactivity among platinum agents. |
| format |
article |
| author |
Ilaria Puxeddu Fiorella Petrelli Maria Elena Guerrieri Stefania Cosio Isabella Del Corso Valeria Rocchi Maria Laura Manca Paola Migliorini Angiolo Gadducci |
| author_facet |
Ilaria Puxeddu Fiorella Petrelli Maria Elena Guerrieri Stefania Cosio Isabella Del Corso Valeria Rocchi Maria Laura Manca Paola Migliorini Angiolo Gadducci |
| author_sort |
Ilaria Puxeddu |
| title |
The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study |
| title_short |
The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study |
| title_full |
The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study |
| title_fullStr |
The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study |
| title_full_unstemmed |
The Role of Skin Tests in the Prevention and Diagnosis of Hypersensitivity Reactions to Platinum Agents in Gynecological Cancer: A Single-Center Italian Retrospective Study |
| title_sort |
role of skin tests in the prevention and diagnosis of hypersensitivity reactions to platinum agents in gynecological cancer: a single-center italian retrospective study |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/3b5a675d8b294e668f62ebf751fc41c9 |
| work_keys_str_mv |
AT ilariapuxeddu theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT fiorellapetrelli theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT mariaelenaguerrieri theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT stefaniacosio theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT isabelladelcorso theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT valeriarocchi theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT marialauramanca theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT paolamigliorini theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT angiologadducci theroleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT ilariapuxeddu roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT fiorellapetrelli roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT mariaelenaguerrieri roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT stefaniacosio roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT isabelladelcorso roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT valeriarocchi roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT marialauramanca roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT paolamigliorini roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy AT angiologadducci roleofskintestsinthepreventionanddiagnosisofhypersensitivityreactionstoplatinumagentsingynecologicalcancerasinglecenteritalianretrospectivestudy |
| _version_ |
1718435172136779776 |