Two neutrophilic dermatoses captured simultaneously on histology

A number of neutrophilic dermatoses are associated with malignancies and their treatment. These rarely occur together in the same patient. A Caucasian 72-year-old male was treated for acute myeloid leukemia (AML) with chemotherapy including daunorubicin and cytarabine. Within 48 hours of commenc...

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Autores principales:	Christina Wlodek, Nidhi Bhatt, Cameron Kennedy
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	neutrophilic dermatosis neutrophilic eccrine hidradenitis Sweet's syndrome Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/3b5d96f45fb04a789f064d8445b7b6a4
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spelling	oai:doaj.org-article:3b5d96f45fb04a789f064d8445b7b6a42021-11-17T08:31:11ZTwo neutrophilic dermatoses captured simultaneously on histology10.5826/dpc.0603a112160-9381https://doaj.org/article/3b5d96f45fb04a789f064d8445b7b6a42016-07-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/111https://doaj.org/toc/2160-9381 A number of neutrophilic dermatoses are associated with malignancies and their treatment. These rarely occur together in the same patient. A Caucasian 72-year-old male was treated for acute myeloid leukemia (AML) with chemotherapy including daunorubicin and cytarabine. Within 48 hours of commencing treatment, he developed pyrexia and, two days later, disseminated non-tender pink plaques on the limbs and trunk. A skin biopsy showed a dermal interstitial infiltrate of lymphocytes, histiocytoid cells and predominantly neutrophils. This extended into the subcutis, where a neutrophilic lobular panniculitis was seen. These findings are consistent with Sweet’s syndrome. In addition, a neutrophilic and lymphocytic infiltrate was also present around eccrine coils and lower ducts. The eccrine epithelium showed squamous metaplasia with dyskeratosis and sloughing into the lumen. These latter findings are consistent with neutrophilic eccrine hidradenitis (NEH). These two histologically distinct entities form part of the neutrophilic dermatoses that have been described in oncology patients with reports of concurrent or sequential occurrence of various neutrophilic dermatoses in the same patient. Ours, however, is only the second reported case of simultaneously captured Sweet’s and NEH in the setting of AML. The most likely explanation is that of an epiphenomenon, whereby the neutrophilic infiltrate extended around the sweat glands in the context of the neutrophilic dermatosis. Christina WlodekNidhi BhattCameron KennedyMattioli1885articleneutrophilic dermatosisneutrophilic eccrine hidradenitisSweet's syndromeDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophilic dermatosis neutrophilic eccrine hidradenitis Sweet's syndrome Dermatology RL1-803
spellingShingle	neutrophilic dermatosis neutrophilic eccrine hidradenitis Sweet's syndrome Dermatology RL1-803 Christina Wlodek Nidhi Bhatt Cameron Kennedy Two neutrophilic dermatoses captured simultaneously on histology
description	A number of neutrophilic dermatoses are associated with malignancies and their treatment. These rarely occur together in the same patient. A Caucasian 72-year-old male was treated for acute myeloid leukemia (AML) with chemotherapy including daunorubicin and cytarabine. Within 48 hours of commencing treatment, he developed pyrexia and, two days later, disseminated non-tender pink plaques on the limbs and trunk. A skin biopsy showed a dermal interstitial infiltrate of lymphocytes, histiocytoid cells and predominantly neutrophils. This extended into the subcutis, where a neutrophilic lobular panniculitis was seen. These findings are consistent with Sweet’s syndrome. In addition, a neutrophilic and lymphocytic infiltrate was also present around eccrine coils and lower ducts. The eccrine epithelium showed squamous metaplasia with dyskeratosis and sloughing into the lumen. These latter findings are consistent with neutrophilic eccrine hidradenitis (NEH). These two histologically distinct entities form part of the neutrophilic dermatoses that have been described in oncology patients with reports of concurrent or sequential occurrence of various neutrophilic dermatoses in the same patient. Ours, however, is only the second reported case of simultaneously captured Sweet’s and NEH in the setting of AML. The most likely explanation is that of an epiphenomenon, whereby the neutrophilic infiltrate extended around the sweat glands in the context of the neutrophilic dermatosis.
format	article
author	Christina Wlodek Nidhi Bhatt Cameron Kennedy
author_facet	Christina Wlodek Nidhi Bhatt Cameron Kennedy
author_sort	Christina Wlodek
title	Two neutrophilic dermatoses captured simultaneously on histology
title_short	Two neutrophilic dermatoses captured simultaneously on histology
title_full	Two neutrophilic dermatoses captured simultaneously on histology
title_fullStr	Two neutrophilic dermatoses captured simultaneously on histology
title_full_unstemmed	Two neutrophilic dermatoses captured simultaneously on histology
title_sort	two neutrophilic dermatoses captured simultaneously on histology
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/3b5d96f45fb04a789f064d8445b7b6a4
work_keys_str_mv	AT christinawlodek twoneutrophilicdermatosescapturedsimultaneouslyonhistology AT nidhibhatt twoneutrophilicdermatosescapturedsimultaneouslyonhistology AT cameronkennedy twoneutrophilicdermatosescapturedsimultaneouslyonhistology
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Two neutrophilic dermatoses captured simultaneously on histology

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