The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy.

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Autores principales:	Michael J. Lukey, Kai Su Greene, Jon W. Erickson, Kristin F. Wilson, Richard A. Cerione
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b613416e0fb4b2589fd4ff157971900
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spelling	oai:doaj.org-article:3b613416e0fb4b2589fd4ff1579719002021-12-02T15:34:56ZThe oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy10.1038/ncomms113212041-1723https://doaj.org/article/3b613416e0fb4b2589fd4ff1579719002016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11321https://doaj.org/toc/2041-1723Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy.Michael J. LukeyKai Su GreeneJon W. EricksonKristin F. WilsonRichard A. CerioneNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Lukey Kai Su Greene Jon W. Erickson Kristin F. Wilson Richard A. Cerione The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
description	Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy.
format	article
author	Michael J. Lukey Kai Su Greene Jon W. Erickson Kristin F. Wilson Richard A. Cerione
author_facet	Michael J. Lukey Kai Su Greene Jon W. Erickson Kristin F. Wilson Richard A. Cerione
author_sort	Michael J. Lukey
title	The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
title_short	The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
title_full	The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
title_fullStr	The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
title_full_unstemmed	The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
title_sort	oncogenic transcription factor c-jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3b613416e0fb4b2589fd4ff157971900
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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

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