Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse

Abstract The maximum value of the first derivative of the invasively measured left ventricular (LV) pressure (+ dP/dtmax or P′) is often used to quantify LV contractility, which in mice is limited to a single terminal study. Thus, determination of P′ in mouse longitudinal/serial studies requires a g...

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Autores principales:	Jorge Enrique Tovar Perez, Jesus Ortiz-Urbina, Celia Pena Heredia, Thuy T. Pham, Sridhar Madala, Craig J. Hartley, Mark L. Entman, George E. Taffet, Anilkumar K. Reddy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b629a7ae5d540dab5db2fcb13cb85d0
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spelling	oai:doaj.org-article:3b629a7ae5d540dab5db2fcb13cb85d02021-12-02T15:23:04ZAortic acceleration as a noninvasive index of left ventricular contractility in the mouse10.1038/s41598-020-79866-y2045-2322https://doaj.org/article/3b629a7ae5d540dab5db2fcb13cb85d02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79866-yhttps://doaj.org/toc/2045-2322Abstract The maximum value of the first derivative of the invasively measured left ventricular (LV) pressure (+ dP/dtmax or P′) is often used to quantify LV contractility, which in mice is limited to a single terminal study. Thus, determination of P′ in mouse longitudinal/serial studies requires a group of mice at each desired time point resulting in “pseudo” serial measurements. Alternatively, a noninvasive surrogate for P′ will allow for repeated measurements on the same group of mice, thereby minimizing physiological variability and requiring fewer animals. In this study we evaluated aortic acceleration and other parameters of aortic flow velocity as noninvasive indices of LV contractility in mice. We simultaneously measured LV pressure invasively with an intravascular pressure catheter and aortic flow velocity noninvasively with a pulsed Doppler probe in mice, at baseline and after the administration of the positive inotrope, dobutamine. Regression analysis of P′ versus peak aortic velocity (vp), peak velocity squared/rise time (vp 2/T), peak (+ dvp/dt or v′p) and mean (+ dvm/dt or v′m) aortic acceleration showed a high degree of association (P′ versus: vp, r2 = 0.77; vp 2/T, r2 = 0.86; v′p, r2 = 0.80; and v′m, r2 = 0.89). The results suggest that mean or peak aortic acceleration or the other parameters may be used as a noninvasive index of LV contractility.Jorge Enrique Tovar PerezJesus Ortiz-UrbinaCelia Pena HerediaThuy T. PhamSridhar MadalaCraig J. HartleyMark L. EntmanGeorge E. TaffetAnilkumar K. ReddyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Enrique Tovar Perez Jesus Ortiz-Urbina Celia Pena Heredia Thuy T. Pham Sridhar Madala Craig J. Hartley Mark L. Entman George E. Taffet Anilkumar K. Reddy Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
description	Abstract The maximum value of the first derivative of the invasively measured left ventricular (LV) pressure (+ dP/dtmax or P′) is often used to quantify LV contractility, which in mice is limited to a single terminal study. Thus, determination of P′ in mouse longitudinal/serial studies requires a group of mice at each desired time point resulting in “pseudo” serial measurements. Alternatively, a noninvasive surrogate for P′ will allow for repeated measurements on the same group of mice, thereby minimizing physiological variability and requiring fewer animals. In this study we evaluated aortic acceleration and other parameters of aortic flow velocity as noninvasive indices of LV contractility in mice. We simultaneously measured LV pressure invasively with an intravascular pressure catheter and aortic flow velocity noninvasively with a pulsed Doppler probe in mice, at baseline and after the administration of the positive inotrope, dobutamine. Regression analysis of P′ versus peak aortic velocity (vp), peak velocity squared/rise time (vp 2/T), peak (+ dvp/dt or v′p) and mean (+ dvm/dt or v′m) aortic acceleration showed a high degree of association (P′ versus: vp, r2 = 0.77; vp 2/T, r2 = 0.86; v′p, r2 = 0.80; and v′m, r2 = 0.89). The results suggest that mean or peak aortic acceleration or the other parameters may be used as a noninvasive index of LV contractility.
format	article
author	Jorge Enrique Tovar Perez Jesus Ortiz-Urbina Celia Pena Heredia Thuy T. Pham Sridhar Madala Craig J. Hartley Mark L. Entman George E. Taffet Anilkumar K. Reddy
author_facet	Jorge Enrique Tovar Perez Jesus Ortiz-Urbina Celia Pena Heredia Thuy T. Pham Sridhar Madala Craig J. Hartley Mark L. Entman George E. Taffet Anilkumar K. Reddy
author_sort	Jorge Enrique Tovar Perez
title	Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
title_short	Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
title_full	Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
title_fullStr	Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
title_full_unstemmed	Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
title_sort	aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b629a7ae5d540dab5db2fcb13cb85d0
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Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse

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