Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study
BackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation. Nevertheless, persistent cold-intolerance exists among a substantial proportion of hypothyroid patients on adequate levothyroxine (LT4)...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:3b64c8aa8f264c64a5697239faeeaec52021-11-19T04:59:45ZEffect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study1664-239210.3389/fendo.2021.785175https://doaj.org/article/3b64c8aa8f264c64a5697239faeeaec52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.785175/fullhttps://doaj.org/toc/1664-2392BackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation. Nevertheless, persistent cold-intolerance exists among a substantial proportion of hypothyroid patients on adequate levothyroxine (LT4) substitution.Materials and MethodsTo assess if skin temperature and activation of BAT during treatment with liothyronine (LT3) differs from that of LT4 treatment, fifty-nine female hypothyroid patients with residual symptoms on LT4 or LT4/LT3 combination therapy were randomly assigned in a non-blinded crossover study to receive monotherapy with LT4 or LT3 for 12 weeks each. Change in supraclavicular (SCV) skin temperature overlying BAT, and sternal skin temperature not overlying BAT, during rest and cold stimulation were assessed by infrared thermography (IRT). In addition, abundance of exosomal miR-92a, a biomarker of BAT activation, was estimated as a secondary outcome.ResultsCold stimulated skin temperatures decreased less with LT3 vs. LT4 in both SCV (mean 0.009°C/min [95% CI: 0.004, 0.014]; P<0.001) and sternal areas (mean 0.014°C/min [95% CI: 0.008, 0.020]; P<0.001). No difference in serum exosomal miR-92a abundance was observed between the two treatment groupsConclusionLT3 may reduce dermal heat loss. Thermography data suggested increased BAT activation in hypothyroid patients with cold-intolerance. However, this finding was not corroborated by assessment of the microRNA biomarker of BAT activation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03627611Betty Ann BjerkreimBetty Ann BjerkreimSara Salehi HammerstadSara Salehi HammerstadHanne Løvdal GulsethTore Julsrud BergTore Julsrud BergSindre Lee-ØdegårdAnbjørg RangbergChristine Monceyron JonassenChristine Monceyron JonassenHelen BudgeDavid MorrisJames LawMichael SymondsMichael SymondsErik Fink EriksenErik Fink EriksenFrontiers Media S.A.articlehypothyroidismbrown adipose tissue (BAT)cold-induced thermogenesisinfrared thermographyliothyroninelevothyroxineDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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hypothyroidism brown adipose tissue (BAT) cold-induced thermogenesis infrared thermography liothyronine levothyroxine Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
hypothyroidism brown adipose tissue (BAT) cold-induced thermogenesis infrared thermography liothyronine levothyroxine Diseases of the endocrine glands. Clinical endocrinology RC648-665 Betty Ann Bjerkreim Betty Ann Bjerkreim Sara Salehi Hammerstad Sara Salehi Hammerstad Hanne Løvdal Gulseth Tore Julsrud Berg Tore Julsrud Berg Sindre Lee-Ødegård Anbjørg Rangberg Christine Monceyron Jonassen Christine Monceyron Jonassen Helen Budge David Morris James Law Michael Symonds Michael Symonds Erik Fink Eriksen Erik Fink Eriksen Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| description |
BackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation. Nevertheless, persistent cold-intolerance exists among a substantial proportion of hypothyroid patients on adequate levothyroxine (LT4) substitution.Materials and MethodsTo assess if skin temperature and activation of BAT during treatment with liothyronine (LT3) differs from that of LT4 treatment, fifty-nine female hypothyroid patients with residual symptoms on LT4 or LT4/LT3 combination therapy were randomly assigned in a non-blinded crossover study to receive monotherapy with LT4 or LT3 for 12 weeks each. Change in supraclavicular (SCV) skin temperature overlying BAT, and sternal skin temperature not overlying BAT, during rest and cold stimulation were assessed by infrared thermography (IRT). In addition, abundance of exosomal miR-92a, a biomarker of BAT activation, was estimated as a secondary outcome.ResultsCold stimulated skin temperatures decreased less with LT3 vs. LT4 in both SCV (mean 0.009°C/min [95% CI: 0.004, 0.014]; P<0.001) and sternal areas (mean 0.014°C/min [95% CI: 0.008, 0.020]; P<0.001). No difference in serum exosomal miR-92a abundance was observed between the two treatment groupsConclusionLT3 may reduce dermal heat loss. Thermography data suggested increased BAT activation in hypothyroid patients with cold-intolerance. However, this finding was not corroborated by assessment of the microRNA biomarker of BAT activation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03627611 |
| format |
article |
| author |
Betty Ann Bjerkreim Betty Ann Bjerkreim Sara Salehi Hammerstad Sara Salehi Hammerstad Hanne Løvdal Gulseth Tore Julsrud Berg Tore Julsrud Berg Sindre Lee-Ødegård Anbjørg Rangberg Christine Monceyron Jonassen Christine Monceyron Jonassen Helen Budge David Morris James Law Michael Symonds Michael Symonds Erik Fink Eriksen Erik Fink Eriksen |
| author_facet |
Betty Ann Bjerkreim Betty Ann Bjerkreim Sara Salehi Hammerstad Sara Salehi Hammerstad Hanne Løvdal Gulseth Tore Julsrud Berg Tore Julsrud Berg Sindre Lee-Ødegård Anbjørg Rangberg Christine Monceyron Jonassen Christine Monceyron Jonassen Helen Budge David Morris James Law Michael Symonds Michael Symonds Erik Fink Eriksen Erik Fink Eriksen |
| author_sort |
Betty Ann Bjerkreim |
| title |
Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_short |
Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_full |
Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_fullStr |
Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_full_unstemmed |
Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_sort |
effect of liothyronine treatment on dermal temperature and activation of brown adipose tissue in female hypothyroid patients: a randomized crossover study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/3b64c8aa8f264c64a5697239faeeaec5 |
| work_keys_str_mv |
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